DNA microarray-based gene expression profiling in diagnosis, assessing prognosis and predicting response to therapy in colorectal cancer
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2012, Vol 66, Issue 0
Abstract
Colorectal cancer is the most common cancer of the gastrointestinal tract. It is considered as a biological model of a certain type of cancerogenesis process in which progression from an early to late stage adenoma and cancer is accompanied by distinct genetic alterations. Clinical and pathological parameters commonly used in clinical practice are often insufficient to determine groups of patients suitable for personalized treatment. Moreover, reliable molecular markers with high prognostic value have not yet been determined. Molecular studies using DNA-based microarrays have identified numerous genes involved in cell proliferation and differentiation during the process of cancerogenesis. Assessment of the genetic profile of colorectal cancer using the microarray technique might be a useful tool in determining the groups of patients with different clinical outcomes who would benefit from additional personalized treatment. The main objective of this study was to present the current state of knowledge on the practical application of gene profiling techniques using microarrays for determining diagnosis, prognosis and response to treatment in colorectal cancer.
Authors and Affiliations
Przemysław Kwiatkowski, Piotr Wierzbicki, Andrzej Kmieć, Janusz Godlewski
Keywords
Related Articles
- EP ID EP66701
- DOI -
- Views 157
- Downloads 0
Prognostic value of microsatellite instability in adjuvant treatment of colorectal cancer
The dynamics of morbidity and mortality in colorectal cancer (CRC) has changed little in recent years and consistently remains at a high level. The carcinogenesis of this type of tumors includes a large number of genetic...
Surowicze stężenia IL-10 i IL-12 odzwierciedlają uzyskiwaną odpowiedź na chemioterapię u dzieci z mięsakami tkanek miękkich, jednak ulegają modyfikacji podczas terapii czynnikiem wzrostu kolonii granulocytów (G-CSF) oraz w przebiegu sepsy
Dehydroepiandrosterone sulfate, osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia nervosa
Background: Only scarce data exist concerning the relationship between dehydroepiandrosterone (DHEA) and/or its sulfate form DHEAS and bone status in adolescents with anorexia nervosa (AN). Aim: We investigated whether...
Primary Immunodeficiency with double strain break DNA (DSBs) and radiosensitvity: clinical, diagnostic and therapeutic implications
Primary Immunodeficiencies (PNO) are a group of about 300 genetic disorders which result from the absence or dysfunction of the major components of the immune system. Among them an important subgroup constitute deficienc...
Yamanaka’s factors and core transcription factors – the molecular link between embryogenesis and carcinogenesis
Oct4 and Sox2 transcription factors (belonging to the Yamanaka’s factor family) and Nanog, named together as core transcription factors of pluripotency, are indispensable to induce and maintain the pluripotency state. Th...