DNA microarray-based gene expression profiling in diagnosis, assessing prognosis and predicting response to therapy in colorectal cancer
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2012, Vol 66, Issue 0
Abstract
Colorectal cancer is the most common cancer of the gastrointestinal tract. It is considered as a biological model of a certain type of cancerogenesis process in which progression from an early to late stage adenoma and cancer is accompanied by distinct genetic alterations. Clinical and pathological parameters commonly used in clinical practice are often insufficient to determine groups of patients suitable for personalized treatment. Moreover, reliable molecular markers with high prognostic value have not yet been determined. Molecular studies using DNA-based microarrays have identified numerous genes involved in cell proliferation and differentiation during the process of cancerogenesis. Assessment of the genetic profile of colorectal cancer using the microarray technique might be a useful tool in determining the groups of patients with different clinical outcomes who would benefit from additional personalized treatment. The main objective of this study was to present the current state of knowledge on the practical application of gene profiling techniques using microarrays for determining diagnosis, prognosis and response to treatment in colorectal cancer.
Authors and Affiliations
Przemysław Kwiatkowski, Piotr Wierzbicki, Andrzej Kmieć, Janusz Godlewski
Keywords
Related Articles
- EP ID EP66701
- DOI -
- Views 164
- Downloads 0
Nowotworowe komórki macierzyste
Teoria istnienia nowotworowych komórek macierzystych (cancer stem cells – CSC) zyskuje coraz większe znaczenie w świecie medycyny. Liczne dowody badań in vivo oraz in vitro wskazują, że to właśnie populacja niezróżnicowa...
Molecular fundamentals of drug interactions in the therapy of colorectal cancer
Rapid advances in the field of chemotherapy have resulted in the introduction of numerous antineoplastic drugs into clinical practice, which increased the efficiency of patient management. Also the prevalent use of combi...
Rola szlaków sygnałowych TGF-β w nowotworach
Cytokina TGF-β wpływa na wzrost i różnicowanie wielu typów komórek oraz homeostazę tkankową. Ponadto, białko to pełni główną rolę w patogenezie licznych chorób. Szlaki sygnałowe indukowane w komórkach nowotworowych przez...
Regulacja melanogenezy: rola cAMP i MITF
W artykule przedstawiono przebieg melanogenezy oraz udział cAMP i czynnika transkrypcyjnego MITF w regulacji tego procesu. Produktami melanogenezy są eu- i/lub feomelaniny powstające w wyniku wieloetapowego procesu utlen...
“Vicious circles” of glioblastoma tumors: vascularization and invasiveness
Glioblastoma multiforme is the most common and a particularly aggressive form of glial primary brain tumors. This malignancy accounts for ca. 70% of all diagnosed cases. Unfortunately, average survival of glioma patients...