Molecular fundamentals of drug interactions in the therapy of colorectal cancer
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Rapid advances in the field of chemotherapy have resulted in the introduction of numerous antineoplastic drugs into clinical practice, which increased the efficiency of patient management. Also the prevalent use of combination treatment based on drug action synergy contributed to the improved clinical effect associated with cytotoxic drug administration. It seems, however, obvious that the multidirectional pharmacotherapy in oncology requires a thorough knowledge of drugs’ pharmaceutical behavior in order to maximize their collective action and prevent the occurrence of unintended drug interactions that could potentially impair treatment effectiveness. In fact, drug interactions constitute a serious problem for current oncology primarily resulting from a narrow therapeutic index specific for the majority of anticancer drugs. This, in turn, indicates that even slight deviations of their pharmacokinetics could cause significant clinical consequences, manifested by alteration of the toxicological profile or reduction of therapeutic efficiency. Hence, the investigation of molecular aspects underlying the mechanisms of various drug interactions seems to be essential for proper and safe patient management. The present article is devoted to the extensive subject of drug interactions occurring in the therapy of colorectal cancer. It presents the available literature data on both positive and negative effects of interactions and it discusses their mechanisms complying with their classification into pharmacokinetic and pharmacodynamic ones.
Authors and Affiliations
Katarzyna Regulska, Beata Stanisz, Miłosz Regulski, Paulina Gieremek
Keywords
Related Articles
- EP ID EP67299
- DOI -
- Views 161
- Downloads 0
Sources of antibiotics in natural environments and their biological role
Nowadays antibiotics are broadly used not only for treatment of bacterial infections but also in nonmedical applications. For many years they have been added as livestock and poultry growth supplements, and they are appl...
Facts and speculations on the infectious nature of Alzheimer’s disease
For over 30 years, a large volume of data has been collected indicating the possibility of an infectious form of Alzheimer’s disease (AD). Using various AD animal models and patients’ brain extracts it has been demonstra...
Rola resweratrolu w regulacji metabolizmu komórkowego
Spożywanie wina w umiarkowanych ilościach wiąże się z obniżonym ryzykiem wystąpienia chorób sercowo-naczyniowych i mózgowo-naczyniowych, chorób naczyń obwodowych, a także nowotworów. Zjawisko to określa się mianem „franc...
The influence of polymorphism of the MUC7 gene on the teeth and dental hygiene of students at a faculty of dentistry in Poland
Objective: The aim of the study was to analyze polymorphism of the MUC7 gene and its correlation with the DMFT value and the Plaque Control Record by O’Leary. Material/Methods: The study was carried out on 158 students o...
Lung cancer stem cells – the role in pathogenesis and progressive growth of cancer
Lung cancer is the main cause of cancer death worldwide. Rapid accurate diagnosis, recognition of risk factors and improvement of treatment efficacy represent the main challenges. An advanced stage of the disease at the...