Does CSF antibodies assay help in differentiating neurocysticercosis from tuberculoma?
Journal Title: IP International Journal of Medical Microbiology and Tropical Diseases - Year 2018, Vol 4, Issue 4
Abstract
Introduction Two common causes of ringdisc enhancing lesions in CT scan or MRI scan of brain are Cysticercosis and tuberculoma It is often difficult to know the cause in a patient with ringdisc lesionsThe gold standard being tissue diagnosis which is often not done or not practical due to procedural complications and most of these lesions carry a benign course The present study was undertaken to test the sensitivity and specificity of CSF antibodies in Definitive cases of Neurocysticercosis and TuberculomaMaterials and Methods A Crosssectional descriptive study was conducted with a sample size of 50 patients The duration of study was for 2 years Consecutive patients visiting the neurology department with complaints of seizures headache and focal neurological deficit and their neuroimaging demonstrating a ringdisc enhancing lesions suggesting either a Cysticercosis or Tuberculoma were included Patients were subjected to a detail clinical history and examination Complete hemogram complete blood chemistry HIV serology and Neuroimaging either MRI or CT brain were doneLumbar puncture was done in all patients if there were no contraindicationsCSF analysis for antibodies against antigens of cysticercosis and antitubercular antibodies were done Antibody estimation is done by ELISA methodResults There were 52 patients in the study of which 26 patients were diagnosed as Neurocysticercosis and 11 patients as Tuberculoma In all 26 patients with Cysticercosis CSF was showing less than 4 cells with normal glucose and protein Out of 11 patients with tuberculoma only one patient CSF study was abnormalCSF Elisa for anticysticeral and antitubercular antibodies were done in all patients and were negative in all themConclusion CSF ELISA test for anticysticercal antibody and anti tubercular antibody test has a low sensitivity and is not helpful in the diagnosis of ring enhancing lesions in the brainKeywords Neurocysticercosis Tubeculoma CSF Antibodies
Authors and Affiliations
Raghunandan Nadig, A K Roy, Thomas Mathew, GRK Sarma, Muralidharan Dr
Keywords
Related Articles
- EP ID EP485878
- DOI 10.18231/2581-4761.2018.0045
- Views 91
- Downloads 0
Organizing a Reference Laboratory for Medical Mycology
The objective is to provide the conceptual basis as well as some specifics needed for establishing a laboratory for mycology. A functional self-contained mycology laboratory, include three definitive areas, a clerical of...
Challenges in Medical Microbiology in Indian scenario in the backdrop of International Health Regulations Compliance
Introduction: The International Health Regulations (IHR) were formulated in 1969 and finally revised in 2005 to develop a universal approach to public health to tackle international spread of diseases so that adequate re...
Antimicrobial resistance pattern of Pseudomonas aeruginosa in a tertiary level hospital in Southern India
Introduction Pseudomonas have now a days become a major cause of nosocomial and community acquired infections They are widely distributed in the hospital environment which makes them difficult to eradicate Paeruginosa ha...
Melioidosis in Andaman’s: A report of two cases and a short review
Melioidosis caused by Burkholderia pseudomallei is an emerging infectious disease in the tropical regions of the world The aetiologic agent is an environmental saprophyte and can be transmitted by percutaneous inoculatio...
Mycological profile of keratomycosis in a tertiary care centre from Pune Maharashtra
Introduction Microbial keratitis remains a leading cause of corneal ulcer and blindness worldwide Mycotic keratitis has emerged as a major ophthalmic problem and contributes to 653 of all corneal infections worldwide Thu...