DRUG TARGETING: BASIC CONCEPTS AND NANOSYSTEMS IN DRUG TARGETING
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 4
Abstract
At present about 95% of all new potential therapeutic have poor pharmacokinetic and pharmacodynamics property. Either they get destroyed before going to systemic circulation or they get poorly absorbed. Hence, there is need to develop the new potential drug system which has significant good pharmacokinetic and pharmacodynamics property. For this purpose the concept of Targeted drug delivery system has been originated by “Paul Ehrlich”. Among the drug carrier it includes polymer, micro particles made of synthetic polymers, microcapsules, quantum dots, magnetic microspheres, liposomes. Liposomes which are micro or nanometric vesicles composed of amphiphillic species have particle size ranging from 20nm to several micrometers. Indeed, liposomes formulations of some drugs have shown a significant increase in therapeutic efficacy and therapeutic indices compared to other non liposomal formulation. In site specific targeted drug delivery, active drug is delivered to very specific preselected compartments with maximum activity while reducing the concentration of drug to normal cells. The drug can be targeted to intracellular sites, virus cells, bacteria cell and parasites using different scientific strategies have proven highly effective. The minimum distribution of the parent drug to the non- target cells with higher and effective concentration at the targeted site certainly maximize the benefits of targeted drug delivery
Authors and Affiliations
Smita T. Kumbhar
Keywords
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