Dyslipidemia in Subclinical Hypothyroidism: A Case-Control Study
Journal Title: Journal of Endocrinology and Diabetes - Year 2018, Vol 5, Issue 1
Abstract
Subclinical hypothyroidism (SCH) affects 7.5-8.5% of women and 2.8-4.4% of men. Overt hypothyroidism is characterized by dyslipidemia, however controversy persists regarding the lipids level in SCH and its clinical significance. Recent evidence shows that T4 replacement therapy may improve lipid profile. The aim of this study is to assess the prevalence of dyslipidemia in SCH, this first study to assess dyslipidemia among patients with SCH in Duhok, Iraq is a case-control study, comparing 60 patients diagnosed with subclinical hypothyroidism to 60 healthy individuals (matched for age and gender). The study conducted at the endocrine clinic at Azadi Teaching Hospital in Duhok Governorate, Kurdistan Region, Iraq from 1st June 2016 to 1st June 2017. Dyslipidemia was much more prevalent in patients with SCH compared to control group (p< 0.001). In further analysis of dyslipidemia total cholesterol and triglyceride levels were statistically higher among cases in comparison to controls (p< 0.001) for both. LDL level was higher among cases in comparison to controls but did not reach statistical significance (p= 0.087). While there was significant difference regarding HDL level among female gender cases and controls (p= 0.003), there was no significant difference regarding difference in HDL level among male gender cases and controls (p= 0.653). SCH is considered atherogenic condition as it increases dyslipidemia and it increases overall cardiovascular risk. It’s important to assess lipid profile and CVS risk in these patients and to treat with levothyroxine when it’s clinically applicable
Authors and Affiliations
Bayar Qasim, Sardar Arif, Ayad Mohammed, Rezvan Abduljabbar
Keywords
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- EP ID EP334034
- DOI 10.15226/2374-6890/5/1/00192
- Views 127
- Downloads 0
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