Early onset neonatal sepsis in relation to prolonged rupture of membranes of more than 18 hours - A prospective study

Journal Title: Medpulse International Journal of Pediatrics - Year 2018, Vol 6, Issue 3


Background: Sepsis is the commonest cause of neonatal mortality globally and is responsible for about 3–50% of the total neonatal deaths in the developing countries. In India, sepsis contributes up to 52% of neonatal deaths in the community and 36% of deaths in hospital newborns. Prolonged rupture of membranes (PROM) is a common and significant cause of early onset sepsis and preterm labour. The evaluation of neonatal sepsis is important and there is an urgent need to know whether the baby has sepsis so as to institute treatment as quickly as possible. Objective: To determine the number of neonates with early onset sepsis in relation to PROM of more than 18 hours. Materials and Methods: Prospective hospital based study conducted at Paediatric Department, KIMS Hospital, Hubli from December 2011 to November 2012. Neonates born to mothers in KIMS hospital, Hubli with history of PROM of more than 18 hours were evaluated clinically and a set of investigations in relation to sepsis done immediately. Statistical Analysis: Data was analyzed using SPSS software for Windows version 20.0, categorical tables, Chi-square values, Fischer extract test and the results correlated. Results: In newborns with PROM >18 hours, the septic screen was positive in 68 cases. Blood culture was positive in 21 neonates; the most common organism grown was Klebsiella. Conclusion: Culture proven sepsis was seen in 21 neonates with PROM >18 hours; the most common organism being Klebsiella. Probable sepsis was detected in 68 neonates. Longer duration of PROM was associated with higher incidence of sepsis

Authors and Affiliations

Remya R Pai, Kala Raman (Kala Raghu), Rajendra V Naidu


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  • EP ID EP448164
  • DOI 10.26611/1014631
  • Views 94
  • Downloads 0

How To Cite

Remya R Pai, Kala Raman (Kala Raghu), Rajendra V Naidu (2018). Early onset neonatal sepsis in relation to prolonged rupture of membranes of more than 18 hours - A prospective study. Medpulse International Journal of Pediatrics, 6(3), 35-39. https://europub.co.uk/articles/-A-448164