Edaravone and Caffeinol are Neuroprotective After Transient Middle Cerebral Artery Occlusion in Rats
Journal Title: Journal of Neurological Sciences-Turkish - Year 2005, Vol 22, Issue 4
Abstract
Background: Edaravone and Caffeinol are two potential stroke treatments. Their mechanisms of action are different. We aimed to confirm the benefit of Edaravone in our stroke model, and explore the effect of combining them together. Methods: Long-Evans rats with transient middle cerebral artery occlusion were assigned to one of 7 groups: (1) Edaravone vehicle, (2) Caffeinol vehicle, (3) Caffeinol; caffeine (10 mg/kg) + ethanol (0.32 g/kg) intravenously (iv) X 2 hours, (4) Edaravone 3 mg/kg bolus iv, and subcutaneously (sc) X 1 after 30 min, (5) Group 4 with additional sc Edaravone on days 1 and 2, (6) Edaravone + Caffeinol; combining groups 3 and 5, but Edaravone delayed until after the Caffeinol infusion completed, (7) Delayed Edaravone; Edaravone as in group 6. Three days later, neurological deficit (NDS) and lesion volume were measured. Results: Caffeinol and Edaravone reduced NDS by 29% (p<0.05) and 43% (p<0.001), and cortical lesion volume by 43% (p<0.001) and 46% (p<0.001) respectively. Repeating Edaravone provided no added benefit, and delaying Edaravone was less effective. Combining Edaravone + Caffeinol provided 65% cortical protection (p<0.001), 32% in striatum (p<0.01), and decreased NDS by 50% (p<0.001). Compared to Caffeinol or Edaravone alone, Edaravone + Caffeinol reduced NDS by 30% and 43% (p<0.05), cortical infarction by 39% and 54% (p<0.05), and sub-cortical infarction by 20% and 25% (p<0.05) respectively. Conclusion: Both Edaravone and Caffeinol reduce cortical infarction and neurological deficits. Combining Edaravone with Caffeinol provides better protection. Edaravone and Caffeinol, and their combination, warrant further evaluation as potentially effective stroke treatments.
Authors and Affiliations
Xiurong ZHAO, Jaroslaw ARONOWSKI, Guang-Hua SUN, Jie ZHANG, Roger STRONG, Yujian ZHANG, James GROTTA
Keywords
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