Effect and safety of Liqing granules in assisting to reduce serum uric acid in rats
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 12
Abstract
ObjectiveTo establish a rat model of hyperuricemia ï¼HUAï¼ï¼ to study the effect of Liqing granules on lowering serum uric acidï¼ and to evaluate its safety .MethodsMale SD rats were randomly divided into solvent control group and model group according to their body weight. For the model groupï¼ serum uric acid ï¼SUAï¼ was determined after 7 days of intra-gastric administration of potassium oxyazinate. The model group were randomly divided into model control groupï¼ positive control groupï¼ and lowï¼ mediumï¼ high dose group based on SUA level. Each group from the model group continued to receive potassium oxyazinate in the morning. The animals in the model groups received 0.5% CMC-Naï¼ 10 mg·kg-1 benzbromarone ï¼Doses by body weightï¼ and Liqing granules 0.6ï¼ 1.2ï¼ 2.4 g·kg-1 ï¼Doses by body weightï¼ï¼ respectively in the afternoon. 0.5% CMC-Na suspension with the same volume was given both in the morning and afternoon for the solvent control group. Levels of SUAï¼ creatinine ï¼CREAï¼ï¼ alanine aminotransferase ï¼ALTï¼ and aspartate transaminase ï¼ASTï¼ were determined after 32 and 45 days administration of the test substance.ResultsSUA of the model group was ï¼218±23ï¼ Î¼mol·L-1 after 7 days of modelingï¼ which was significantly higher than that of the solvent control group ï¼P<0.001ï¼. After 32 days administration of the test substanceï¼ SUA didnât significantly decrease in each dose group ï¼P>0.05ï¼. CREA in the medium and high dose groups significantly decreased ï¼P<0.05ï¼. After 45 days administration of the test substanceï¼ SUA in each dose group was significantly decreased ï¼P<0.001ï¼ï¼ but CREAï¼ ALTï¼ and AST were not significantly different in each dose group in comparison with the model control group ï¼P>0.05ï¼.ConclusionLiqing granules can assist in lowering blood serum uric acid in the rat HUA modelï¼ and no damage to liver and kidney function is found.
Authors and Affiliations
HU Peili,ZHENG Jifan,LIU Shibo,ZHANG Luyong,LIU Ting,MA Libo,ZHANG Li,LI Bo,
Keywords
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