Effect of age and gender on QT interval
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Background: The sudden cardiac death syndrome has a large preponderance in men compared to women and that too in older age group. Various population studies have demonstrated four- to seven-fold increase of sudden cardiac death among men compared with women. As coronary event risk increases in post-menopausal women, sudden cardiac death risk increases proportionately. Corrected QT interval measurements may predict the chances of increased risk of sudden cardiac death in an apparently healthy individual. Aims and Objectives: The objective of the study was to find any independent association between age and gender on the QT-corrected interval. Materials and Methods: This study included 48 healthy men and 32 healthy women between 17 and 68 years age divided into three groups: Young (<30 years), middle-aged (30-60 years), and the elderly (>60 years). Standard supine 12 lead electrocardiographic was done in these subjects, and statistical analysis was done. The cutoff points for QTc were ≤450 ms (normal), 451 to 470 ms (borderline), and >470 ms (prolonged), in case of women, and ≤430 ms (normal), 431 to 450 ms (borderline), and >450 ms (prolonged) for men. Results: QTc was found to be 374.9 ± 31 (ms) in the young group, 386.3 ± 14.8 (ms) in middle-aged group, and 414.5 ± 11.8 (ms) in the elderly group. Males had longer QTc than the females in the young- and the middle-age groups. Conclusion: Age significantly correlated (r = 0.475) with QT and QTc interval in healthy subjects. Gender was a poor predictor of QT interval.
Authors and Affiliations
Sudeep Satpathy, Smita Satpathy, Prakash Kumar Nayak
Keywords
Related Articles
- EP ID EP451746
- DOI 10.5455/njppp.2018.8.0832304092017
- Views 71
- Downloads 0
Protective potential of ginseng and silymarin on the liver and kidney of ethanol-treated mice (Mus musculus)
Background: Alcohol use and abuse have been rampant worldwide, and therapeutic regimen has been sought for to ameliorate changes brought about by such. Herbal medicines have been mostly used due to their inherent propert...
Impact of horizontal and vertical integration: Learning and perception in first-year medical students
Background: Medical field and its curriculum is dynamic in nature which keeps on adding huge data each year, thus overburdening the students with content information. Most of the colleges in India teach subject in isolat...
Comparative study of pulmonary functions in swimmers and badminton players of Indore city
Background: Exercise performed regularly is beneficial to the body. The previous studies in this field have shown that sportspersons have higher values of lung volumes in comparison to their control counterparts who are...
Actualizing mastery learning in preclinical medical education through a formative medical classroom
Assessment has one of the most significant influences on student learning. Since assessments tend to direct students’ learning efforts toward the intended learning outcomes, it is prudent to consider assessment as learni...
Assessment of knowledge, attitude, and practices of pharmacovigilance and adverse drug reaction reporting among final year medical students - A questionnaire-based study in a tertiary care hospital in Goa
Background: Pharmacovigilance has a significant role in the rational use of medicines by providing information about adverse drug reactions (ADRs). ADRs can lead to significant mortality and morbidity in the health-care...