Effect of age and gender on QT interval
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 2
Abstract
Background: The sudden cardiac death syndrome has a large preponderance in men compared to women and that too in older age group. Various population studies have demonstrated four- to seven-fold increase of sudden cardiac death among men compared with women. As coronary event risk increases in post-menopausal women, sudden cardiac death risk increases proportionately. Corrected QT interval measurements may predict the chances of increased risk of sudden cardiac death in an apparently healthy individual. Aims and Objectives: The objective of the study was to find any independent association between age and gender on the QT-corrected interval. Materials and Methods: This study included 48 healthy men and 32 healthy women between 17 and 68 years age divided into three groups: Young (<30 years), middle-aged (30-60 years), and the elderly (>60 years). Standard supine 12 lead electrocardiographic was done in these subjects, and statistical analysis was done. The cutoff points for QTc were ≤450 ms (normal), 451 to 470 ms (borderline), and >470 ms (prolonged), in case of women, and ≤430 ms (normal), 431 to 450 ms (borderline), and >450 ms (prolonged) for men. Results: QTc was found to be 374.9 ± 31 (ms) in the young group, 386.3 ± 14.8 (ms) in middle-aged group, and 414.5 ± 11.8 (ms) in the elderly group. Males had longer QTc than the females in the young- and the middle-age groups. Conclusion: Age significantly correlated (r = 0.475) with QT and QTc interval in healthy subjects. Gender was a poor predictor of QT interval.
Authors and Affiliations
Sudeep Satpathy, Smita Satpathy, Prakash Kumar Nayak
Keywords
Related Articles
- EP ID EP451746
- DOI 10.5455/njppp.2018.8.0832304092017
- Views 76
- Downloads 0
Immediate effect of contract-relax antagonist-contract method on iliopsoas muscle and hamstring muscle stretching in chronic non-specific low back pain
Background: Low back pain (LBP) is a common musculoskeletal problem in recent days, and 85% of LBP is NSLBP. Studies have shown that psoas syndrome can be the cause of pain in lumbosacral region in a clinical scenario. A...
Blood group distribution and its relationship with bleeding time and clotting time
Background: Blood group plays a vital role in the field of transfusion medicine. The relationship between bleeding time, clotting time, and blood group is important in certain clinical conditions such as epistaxis...
Variation of intraocular pressure with age and gender
We read with interest article ‘‘Variation of Intraocular Pressure with Age and Gender’’ by Jeelani et al[1] and we would like to highlight few facts. All intraocular pressure measurements as was stated in the ar...
Correlation between chronic rhinosinusitis and laryngopharyngeal reflux
Background: Chronic rhinosinusitis (CRS) is a major Ear, Nose and Throat disease and there are higher numbers of refractory cases poorly responding to medical and surgical treatment. Laryngopharyngeal reflux (LPR) is sai...
Hypoxia-induced autophagy in hepatocellular carcinoma and anticancer therapy
Autophagy is a genetically programmed dynamic process for the lysosomal degradation and recycling of bulk cytoplasmic contents, abnormal proteins, and damaged organelles. Along with cellular homeostasis maintenance, auto...