EFFECT OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN-II RECEPTOR BLOCKERS ON PROTEINURIA OF HYPERTENSIVE PATIENTS IN STANDARD CARE PRACTICE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: This study investigated the effect of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin-ii receptor blockers (ARBs) on protein creatinine index (PCI) of patients with hypertension in a standard care practice.Methods: This retrospective study was carried out in a tertiary hospital. Hypertensive patients were randomly selected and screened based on inclusion and exclusion criteria. PCI values were obtained from the patient’s medical record.Results: No significant differences were observed in the percentage of patients with proteinuria (PCI ≥20 mg/mmol creatinine) at pre-and post-treatment among the patients treated with ACEI, ARB or non-ACEI/ARB. Patients treated with ACEI (-10 mg/mmol creatinine; IQR-37.5-+10; p<0.046) and ARB (-10 mg/mmol creatinine; IQR-30-+10; p<0.048) showed significant reduction in PCI values at post-treatment compared to the non-ACEI/ARB group (+5 mg/mmol creatinine; IQR 0-+32.5).Conclusion: Our findings demonstrated that standard care practice, the therapy of ACEI and ARB did not sufficiently reduce the number of patients with proteinuria but could reduce progression of the proteinuria.Â
Authors and Affiliations
Mohd Makmor Bakry, Normi Hamdan
Keywords
Related Articles
- EP ID EP578124
- DOI -
- Views 29
- Downloads 0
METHOD DEVELOPMENT FOR SIMULTANEOUS ANALYSIS OF MARKER SCOPOLETINE, ANDROGRAPHOLIDE, QUERCETIN, AND LUTEOLIN IN ANTIHYPERTENSION JAMU FORMULATION USING RP-HPLC
Objective: The aim of this research was to develop a method of simultaneous analysis marker compounds in antihypertension jamu formulation using reverse phase high performance liquid chromatography (RP-HPLC).Methods: Sta...
OPTIMIZATION OF PANTOPRAZOLE ENTERIC PELLETS COATING PROCESS BY QBD: EFFECT OF COATING PROCESS VARIABLES ON THE INTERMEDIATE QUALITY OF THE PRODUCT AND SCALE UP
Objective: The aim of this study was to optimize pantoprazole enteric coating process based on Quality by Design (QbD) principle and successful scale up.Methods: The critical process parameters (CPP) were identified base...
EVALUATION OF THE ANTILEISHMANIAL EFFICACY OF MEDICINAL PLANT CHENOPODIUM ALBUM LINN. AGAINST EXPERIMENTAL VISCERAL LEISHMANIASIS.
Objective: Visceral leishmaniasis is a neglected tropical disease resulting in death if not properly treated. The ongoing search for better leishmanicidal compounds has brought herbal drugs in to the limelight as safe an...
3D QSAR AND DOCKING STUDY OF INDOLE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS
Objective: Non-steroidal anti-inflammatory agents (NSAIDs) continue to be one of the most widely used groups of therapeutic agents. QSAR (quantitative structure-activity relationship) approach is a very useful and widesp...
PROBABILITY ESTIMATION ON THE RISK OF MORTALITY OF PATIENTS WITH END-STAGE RENAL DISEASE
The kidneys perform life-maintaining functions like monitoring and regulating body fluids. These excrete excess fluids from the body and retain the substances necessary for the body’s continuing function. If the kidney...