EFFECT OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN-II RECEPTOR BLOCKERS ON PROTEINURIA OF HYPERTENSIVE PATIENTS IN STANDARD CARE PRACTICE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: This study investigated the effect of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin-ii receptor blockers (ARBs) on protein creatinine index (PCI) of patients with hypertension in a standard care practice.Methods: This retrospective study was carried out in a tertiary hospital. Hypertensive patients were randomly selected and screened based on inclusion and exclusion criteria. PCI values were obtained from the patient’s medical record.Results: No significant differences were observed in the percentage of patients with proteinuria (PCI ≥20 mg/mmol creatinine) at pre-and post-treatment among the patients treated with ACEI, ARB or non-ACEI/ARB. Patients treated with ACEI (-10 mg/mmol creatinine; IQR-37.5-+10; p<0.046) and ARB (-10 mg/mmol creatinine; IQR-30-+10; p<0.048) showed significant reduction in PCI values at post-treatment compared to the non-ACEI/ARB group (+5 mg/mmol creatinine; IQR 0-+32.5).Conclusion: Our findings demonstrated that standard care practice, the therapy of ACEI and ARB did not sufficiently reduce the number of patients with proteinuria but could reduce progression of the proteinuria.Â
Authors and Affiliations
Mohd Makmor Bakry, Normi Hamdan
Keywords
Related Articles
- EP ID EP578124
- DOI -
- Views 68
- Downloads 0
CATIONIC PEPTIDE LACTOFERRICIN B INHIBITS GLUTATHIONE S-TRANSFERASE P1 FROM HUMAN PLACENTA AND BREAST CANCER CELL LINE MDA-MB-231 PREVENTING ANTICANCER DRUG METABOLISM
Objective: To investigate the interaction of LfcinB (Lactoferricin B) with GSTP1 (Glutathione S-Transferase P1) from human placental and breast cancer cell line MDA-MB-231.Methods: We examined the interaction of Lfcin B...
A NEW NAPHTHOQUINONE ISOLATED FROM POLYGONUM MULTIFLORUM (POLYGONACEAE)
Objective: This research is mainly focused towards isolation and structural elucidation of pure compounds from the extract and fractions of Polygonum multiflorum through silica gel column chromatography.Methods: The air...
LYSOSOMAL MEMBRANE AND PROTEIN STABILIZATION BY DALBERGIA SISSOO (FAMILY: FABACEAE): IN VITRO ANTI-INFLAMMATORY ACTIVITY
Objective: Plants of the genus Dalbergia are reported to be useful in the treatment of arthritis, gonorrhoea and rheumatic pains. Present study was aimed to investigate the in vitro anti-inflammatory activity of ethanol...
CHEMICAL COMPOSITION OF THE HEXANE EXTRACT OF LEAVES OF AZIMA TETRACANTHA (LAM)
Objective: In the present study, the phytochemical constituents of hexane extract from Azima tetracantha (AT) leaves were done by using Gas Chromatography Mass Spectrometry analysis technique (GC-MS). Azima tetracantha h...
PLANT PROFILE, PHYTOCHEMISTRY AND PHARMACOLOGY OF SPATHODEA CAMPANULATA P. BEAUVAIS (AFRICAN TULIP TREE): A REVIEW
Plants have been used as one of the important source for treating various diseases of human beings since ancient times. Numbers of plants are mentioned in different traditional system of medicine, among them Spathodea ca...