Effect of Aqueous Extracts From Hildegardiabarteri Leaves on Lipid Metabolism of Wistarrats: Possible Implication In Arterial Pressure Variation
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 1
Abstract
The aim of this work is to evaluate the impact of aqueous extracts of the leaves of Hildegardiabarteri on the lipid metabolism of wistar rats: possible involvement in blood pressure variations.To achieve our goal an aqueous powder extract of the dried leaves of Hidegardiabarteri was made with a yield of 13.18% and then the phytochemical screening (screening) was carried out by the method of Houghton and Raman in order to identify the phytochemicals Who are present there. This test reveals that our extract is rich in bioactive molecules extractable by water of which: an abundance of tannins, flavonoids, mucilages, reducing compounds, saponosides, triterpenoids, coumarins of quinone derivatives and catechic tannins or Condensed (not abundant). We had 09 lots of 02 rats (180-220g of pc). After a fasting of 18 hours, by oesophageal gavage, the batch (Diuresis base) received only distilled water, lot2 received furosemide alone at 20mg / kg bw and those 3- 9 received it Aqueous extract of the leaves of Hildegardiabarteri at the respective doses: 10; 25; 50; 67.5; 100; 135 and 202.5 mg / kg body weight. Diuretic activity (on urine) and biochemical (blood) assays such as: blood glucose, triglyceride, total cholesterol, LDL and HDL were performed 24 hours after gavage. From this study it appears that the aqueous extract of the leaves of Hildegardiabarteri would have a modest diuretic activity in 6 H and a significant 24H at the dose of 67.5mg / kg bw thanks to the presence of flavonoids (flavones). Analysis of the biochemical parameters revealed that extracts of Hildegardiabarteri leaves at a dose of 67.5 mg / kg bw would lead to a significant decrease in blood glucose levels due to insulin secretion by β cells or Hypoglycemic mechanisms (lipogenesis), hypertriglyceridaemia which is a consequence of lipogenesis or a side effect of diuretics, and a decrease in LDL cholesterol. Of all these observations, it would be beneficial to use aqueous extracts of the leaves of Hildegardiabarteri to lower blood pressure values above normal. Thus, the antihypertensive dose of Hildegardiabarteri would be less than or equal to the dose of 10 mg / kg bw
Authors and Affiliations
Hoteyi Ismael,, Michodjehoun Loetitia,3, Houndeffo Tiburce, Agonvonon Faith,, Ahokpe Melanie, sezan Alphonse*
Keywords
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