Effect of Aqueous Leaf Extract of Vernonia Amygdalina on Blood Glucose and Lipid Profile of Alloxan-Induced Diabetic Rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 5
Abstract
The effects of orally administered aqueous leaf extract of Vernonia amygdalina on serum glucose and lipid profile of albino rats were determined. Adult healthy rats of both sexes of about eleven weeks old were randomly assigned into six groups following acclimatization to laboratory and handling conditions. Animals in group A were not intoxicated (normal control) while group B were intoxicated and were gives access to food and water. Animals in groups C, D, E and F were intoxicated and were treated with insulin (40mg/kg), Atorvastatin(30mg/kg), low dose (200mg/kg) and high dose (400mg/kg) extracts of Vernonia amygdalina respectively. Diabetes was induced with a single dose of alloxan (100mg/kg) body weight and serum glucose was taken 72h after induction of confirm diabetes. Treatment regimes of hyperglycemia and hypalipidemia started on the 4th and 8th day of the experiment respectively. The result obtained from the phytochemical analysis showed that the aqueous extract of Vernonia amygdalina gave positive reactions for tannins, flavonoids, alkaloids, terpenoids, Saponins and polyphenols. The extracts decreased blood glucose in a dose independent fashion. The extract exhibited significant decrease in triglyceride (TG) total cholesterol (TC), low density lipoprotein (LDL) in the alloxan monohydrate intoxicated rats whereas high density lipoprotein (HDL) was increased. The bioefficacy of the herb extracts was significant when compared to the reference drugs (insulin and atorvastatin). These findings are of medical, nutritional and industrial importance in view of its observed possible applications.
Authors and Affiliations
Ukpabi Chibueze, Nwankwo Juliet, Eshie Tochukwu, Isu John
Keywords
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- EP ID EP415682
- DOI 10.9790/3008-1305051317.
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