Prevalence of Aminoglycoside Resistance in Clinical Isolates of Pseudomonas aeruginosa.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 1
Abstract
Pseudomonasaeruginosa is one of the leading causes of nosocomial infections. Severe infections such as pneumonia or bacteremia are associated with high mortality rates and are often difficult to treat, as the usefulanti-pseudomonial agents are limited. Moreover, P. aeruginosa exhibits remarkable ability to acquire resistance to these agents, and so surveillance to keep abreast of information on susceptibility pattern is crucial. In this study 114 isolates from various specimens previously identified as Pseudomonasspp in LUTH Medical Microbiology Laboratory was collected and identified using oxidase test and Pseudomonas centrimide agar. After identification process 56 of the isolates were found to be P. aeruginosa. The resistance pattern of Pseudomonasaeruginosa to aminoglycosides isolated in LUTH was investigated by disc diffusion method. Amongst the aminoglycosides tested, kanamycin had the highest resistance rate of 71.4%, followed by netilimicin, gentamicin and amikacin showing resistance rate of 67.8%, 44.6% and 35.71 respectively. The result of this study revealed that the resistance rate is high.Surveillance studies are crucial in monitoring antimicrobial susceptibility patterns and selecting empirical treatment regimen. Therefore it is suggested that there is a need for correct, high dosing and combination therapy to minimize the risk of resistance development in cases of P. aeruginosa infections.
Authors and Affiliations
Akomolafe . , E. Ugonma, Adewoyin, A. Esther, Wemambu I. Irene
Keywords
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- EP ID EP383391
- DOI 10.9790/3008-11141923 .
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