Tranexamic Acid Use in the Total Hip and Total Knee Arthroplasty Population at an Academic Medical Center: a Retrospective Review of Postoperative Outcomes
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
Purpose: Excessive blood loss and subsequent blood transfusions in orthopedic procedures have been associated with considerable morbidity and mortality. The primary objective of this study was to determine the incidence of perioperative blood transfusion after hip or knee arthroplasty with the use of tranexamic acid (TXA) versus standard of care. Methods: Any adult patient who underwent a total hip or knee arthroplasty between October 1, 2012 and September 30, 2015 was eligible for inclusion. Patients received 1000 mg of intravenous TXA preoperatively. Results: Two hundred ninety-eight patients were included, 148 in the TXA group, and 150 in the standard of care group. In the TXA group, 30 patients required a blood transfusion, versus 48 patients in the standard of care group (p=0.021). Conclusion: TXA was associated with a significantly lower need for blood transfusion and shorter median hospital length of stay without an increase in thromboembolic complications.
Authors and Affiliations
Brianne E. Kaufman, Pharm. D, Julie A. Murphy, FASHP, FCCP,, Natalie Tuttle,, BCPS,1 Daniel Gehling, MD3
Keywords
Related Articles
- EP ID EP388365
- DOI 10.9790/3008-1202030105
- Views 45
- Downloads 0
Evaluation of Immune Response to Measles Virus Antigen
Increasing of measles infection cases in last few years is an important issue, which must be dealing with to assess the reasons. Immunizing lab animals with measles vaccine to is a better way understanding of vaccine-ind...
Anti diabetic activity of the stem bark extract and fractions of Faidherbia albida Del. (Mimosaceae) in murine model.
Background: In our continued search for potent anti-diabetic compound(s) from plants and natural sources, we tested crude extract and fractions of the stem bark of Faidherbia albida - a plant traditional used in the mana...
Screening of Analgesic Activity of Methanolic Extract and Its Fractions of Alternanthera Pungens
The purpose of the present study was to prepare the methanolic extract and various fractions of whole plant of Alternanthera pungens and to perform preliminary phytochemical analysis and screening of analgesic activity u...
“Diseases Caused By Common Intestinal Protozoa of Humans: Symptoms, Prevention and Treatment, a Review of Literature”
Background: In the world there are plenty of parasites such as intestinal parasites and freshwater parasites. Protozoa is one of the most well-known intestinal parasites; which also lives in humans’ intestine. Those whic...
Assessment of Airborne Fungi in an Indoors Laboratory Toilet
Fungi are ubiquitous in both indoors and outdoors environment, exposures to them result to allergies, infection and other adverse health conditions. The assessment of indoor fungi prevalent in six toilets (Biotechnology...