Screening of Analgesic Activity of Methanolic Extract and Its Fractions of Alternanthera Pungens
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
The purpose of the present study was to prepare the methanolic extract and various fractions of whole plant of Alternanthera pungens and to perform preliminary phytochemical analysis and screening of analgesic activity using Tail Immersion method on Swiss albino mice. The whole plant of Alternanthera pungens was collected, powdered and extracted with methanol by maceration method. The obtained methanolic extract was fractioned into various fractions (P2 and C2) using different solvents of increasing order of polarity viz., Petroleum ether and chloroform successively and the residue left over is Hydro alcoholic fraction (H2). Preliminary phytochemical analysis of the obtained extract and fractions revealed the presence of steroids, triterpenoids, phenols and flavonoids rich in methanolic and chloroform fractions (M2 and C2). The extract and its fractions were significantly (p<0.001) reduced the pain as compare to the control group. Among all extract and fractions chloroform fraction (C2) was found to possess good analgesic activity.
Authors and Affiliations
G. Kalpana, K. Sruthi, Zeenath Banu, M. Sumakanth, A. Ravindernath, D. Jaya Prakash
Keywords
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- EP ID EP395667
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