Effect of azelaic acid attenuates ethanol-induced mitochondrial dysfunction, oxidative stress, and apoptosis in human Chang liver cells
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 11
Abstract
The intake of alcohol is a distressing global health problem and ethanol drunkenness has been categorized by hepatic toxicity and oxidative stress resulted in alcoholic liver disease (ALD). Ethanol is a lipophilic substance which promptly distributes to the cell membrane triggering damage to proteins, carbohydrates, lipids and nucleic acids. Oxidative stress plays an important role in ethanol-induced hepatotoxicity, and therefore antioxidants are developing as an important tool in inhibiting alcoholic liver diseases. This study was performed to evaluate the effect of azelaic acid on ethanol-induced toxicity. Azelaic acid is a naturally occurring saturated dicarboxylic acid and is known to possess profound anti-inflammatory and antioxidative effects. Ethanol (30 mM) treatment to Chang liver cells exhibited loss of cell membrane integrity, increased ROS generation, induced mitochondrial dysfunction, and DNA damage, increased the levels of lipid peroxidation, decreased the levels of antioxidants and increased the levels of proapoptotic markers such as Bax, caspase -8,-9 and -3 as compared to the control. In contrast, all there above parameters were regressed when the cells were treated with azelaic acid (500 µM). These findings suggesting that the marked hepatoprotective efficacy of azelaic acid against ethanol-induced liver cell damage.
Authors and Affiliations
Dr. N. Nalini
Keywords
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