EFFECT OF BUSPIRONE : AN ANXIOLYTIC DRUG ON BLOOD GLUCOSE IN HUMANS
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 2
Abstract
The present study investigated the effect of an antianxiety drug, buspirone on blood glucose and plasma insulin level concerning the role of 5-HT1A receptors in blood glucose regulation in healthy humans. Twelve healthy male volunteers were administered single oral doses of buspirone (10 mg) or placebo, in a randomized, crossover way, followed by oral glucose load (75 gm in 200 ml) at reported Tmax i.e. the time of peak plasma concentration of the respective administered drug. The blood samples were collected as predose, postdose and post oral glucose load at 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 hr to investigate the effect of buspirone or placebo at basal blood glucose and plasma insulin level and after oral glucose load induced (postprandial) blood glucose and plasma insulin level. Blood glucose and plasma insulin concentrations were estimated by glucose hexokinase method and enzyme linked immunosorbent assay (ELISA) method respectively. The concentration of blood glucose was significantly (p
Authors and Affiliations
S. K. Ojha , M. Nandave , C. Sharma
Keywords
Related Articles
- EP ID EP159859
- DOI -
- Views 81
- Downloads 0
OXIDATIVE STRESS AND CALCIUM-PHOSPHORUS LEVELS IN RHEUMATOID ARTHRITIS
Generation of reactive oxygen species is an important factor in the development and maintenance of rheumatoid arthritis (RA) in humans. This study was undertaken to investigate interplay among oxidants, antioxidants and...
BLOOD ZINC PROTOPORPHYRIN, SERUM TOTAL PROTEIN, AND TOTAL CHOLESTEROL LEVELS IN AUTOMOBILE WORKSHOP WORKERS IN RELATION TO LEAD TOXICITY: OUR EXPERIENCE
Blood zinc protoporphyrin (ZPP), serum total protein (TP), and total cholesterol (TC) levels in automobile workshop workers in relation to lead toxicity were analysed. In the present study, automobile workshop workers...
COMPARING AGE-WISE REFERENCE INTERVALS FOR SERUM CREATININE CONCENTRATION IN A “REALITY CHECK” OF THE RECOMMENDED CUT-OFF
An increase in the communication within the healthcare services, both nationally and internationally, has strengthened the need for harmonization of measurements and reference intervals in laboratory medicine. In the p...
AIMS OF IFCC AND MY OWN GOALS
CHORONIC EFFECTS OF LAMOTRIGINE ON LIVER FUNCTION IN ADULT MALE RATS
A number of newly developed antiepileptic drugs are currently in use, among them Lamotrigine (LTG) is more common. Despite the extensive use of this drug, it has not been possible to predict the side effects especially...