EFFECT OF BUTYLPARABEN ON TOTAL UTERINE TISSUE PROTEIN IN ADULT C3H ALBINO MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 11
Abstract
In recent years, many environmental pollutants are found to posses estrogenic properties and thus these compounds are known as xenoestrogen or environmental estrogen. These environmental pollutants are present in wide variety of daily used products of human including variety of pharmaceutical and personal care products, foodstuff and products for children. Butylparaben is used in various cosmetics as a preservative like eye care make up products, sunscreen, facial products and skin anti aging products. Many experimental studies in in vivo and in vitro system have shown that butylparaben shows estrogenic activity. In this experiment the effect of butylparaben on studied the total uterine tissue protein in adult C3H albino mice was was studied by lowry method. Four doses of butylparaben 10 mg/Kg body weight/day, 50 mg/Kg body weight/day, 100 mg/Kg body weight/day and 500 mg/Kg body weight/day was administered for 7 consecutive days through subcutaneous route of administration. In the experiment olive oil was used as vehicle control and 17β estradiol was used as positive control. After 7 days of exposure butylparaben was found to increase total uterine tissue protein in adult C3H albino mice.
Authors and Affiliations
Pallabi Goswami, J. C Kalita
Keywords
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