Effect of Chromium(III) -Amino acid (1:3)Complexes on High Sucrose Induced Insulin Resistance, Lipid Abnormalities - Oxidative Stress in Male Sprague Dawley Rats
Journal Title: Journal of Diabetes and Obesity - Year 2015, Vol 2, Issue 1
Abstract
This study was carried out to assess the anti-hyperglycaemic effects if any of novel synthetic binary chromium (III)-amino acid complexes in a high sucrose (HS) induced insulin resistance (IR) and or impaired glucose tolerant male Sprague Dawley (SD) rat model. Aqueous solutions of chromium chloride hexahydrate (CrCl3.6H2O) and D/L amino acids were mixed in 1:3 molar ratios, refluxed at 80°C for 4 hours and the resultant crude greenish-violet solid was extracted with acetone, dried in a hot air oven and their elemental composition and structure were determined. The chromium- amino acid [Cr-(AA)3]complexes were administered orally(~ 45 μg/kg body weight/day up to 12weeks) to adult male SD rats in which IR and or impaired glucose tolerance were induced by feeding a HS diet. In line with literature reports, Cr-D-(Phe)3 complex improved insulin sensitivity and oral glucose tolerance in the HS fed rats. Interestingly, Cr-L-(Phe)3 complex also improved these parameters. Increased phosphorylation of insulin receptor substrate-1 and Akt and increased glucose transporter-4expression in skeletal muscle were associated with these changes suggesting modulation of insulin sensitivity by Cr-L/D-(Phe)3 complexes. Further, sub chronic administration of Cr-(AA)3 complexes significantly improved lipid metabolism. Modulation of oxidative stress and/ or antioxidant status of the animals seem to be associated with/underlie these beneficial effects in HS induced insulin resistant SD rats.
Authors and Affiliations
Raghunath Manchala
Keywords
Related Articles
- EP ID EP417820
- DOI 10.15436/2376-0494.15.016
- Views 117
- Downloads 0
Prolonged High-Fat Diet Feeding of WHHLMI Rabbits does Not Aggravate Metabolic or Cardiac Dysfunction
emsp emsp Myocardial infarction MI -prone Watanabe hereditary hyperlipidemic WHHLMI rabbits were reported to spontaneously but slowly develop MI associated with enhanced coronary atherosclerosis and metabolic syn...
Determining the Development of Insulin Resistance in Older Adults of the NuAge cohort Using Trajectory Modeling of the Homeostatic Model Assessment of Insulin Resistance Score
Background: Age-associated body composition changes increase the risk of developing insulin resistance. Identifying these subjects in epidemiological studies is challenging. Objective: Identify insulin-resistant subjects...
Determinants of Misperception of Weight Status Among a Community of Adults in the Region of Sousse, Tunisia
Aim: To determine the prevalence of misperception of body weight status among Tunisian adults in the region of Sousse and examine its associated factors. Materials and Methods: The studied population was randomly selecte...
Relationships between Weight, Adiposity, Functional Status, and Left Ventricle Characteristics in Overweight and Obese Patients with Heart Failure
Aims: This study was conducted to examine the relationship between adiposity and functional status (i.e. peak oxygen consumption [VO2max]), and left ventricular (LV) structural characteristics (i.e., LV ejection fraction...
Effect of Bariatric Surgery on Glycemic Control in a Military Training Facilitytary Training Facility
Background: The objective of the study was to evaluate the effects of gastric bypass surgery on diabetic and pre-diabetic patients. Outcome variables were diabetic status, BMI, and if patients were able to discontinue pr...