EFFECT OF CLOMIPHENE CITRATE ON GONADOTROPIN HORMONES FSH, LH AND TESTOSTERONE LEVELS IN MICE OFFSPRING
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 8
Abstract
Infertility can cause considerable social, emotional and psychological stress. Ovulatory dysfunction is one of the most common causes of reproductive failure in sub-fertile and infertile women. There are several approaches to ovulation induction therapy for the management of women with ovulatory disorders. Fertility drugs are spreading worldwide fast and therefore many studies have reviewed the association between the use of these drugs and physiological, biochemical and histopathological alterations. The results of present study showed that there were observed effects of Clomiphene citrate (Clomid)® on albino mice offspring’s hormones level. Treating mothers with CC doses 0.2 and 0.3 mg/day caused high increasing and variation in gonadotropin hormones FSH, LH and testosterone (T) levels comparing to control and between males & females also as was clearly noticed on the new offspring of the treated mothers with CC.
Authors and Affiliations
Wejdan M. Henawi
Keywords
Related Articles
- EP ID EP618411
- DOI -
- Views 182
- Downloads 0
THE ANTIBACTERIAL EFFECT OF FLAXSEED EXTRACT ON SELECTIVE ORAL PATHOGENS - COMPARATIVE IN VITRO STUDY
Introduction: Flaxseed from the flax plant (Linum usitatissimum), which has been cultivated for domestic use since prehistoric times. This study aims to investigate presence of antibacterial effect of flaxseed extract ag...
SYNTHESIS, CHARACTERISATION, ANTIMICROBIAL EVALUATION OF 2-HYDROXY PHENYL THIAZOLIDINE-4-ONE DERIVATIVE
A new series of N-(2-(2-hydroxyphenyl)-4-oxothiazolidin-3-yl) isonicotinamide derivatives were synthesized by the reaction of schiff base (Isoniazid and 2 hydroxy benzaldehyde) with mercaptoacetic acid respectively. The...
ANTIPLASMODIAL ACTIVITY OF THE ETHANOL LEAF EXTRACT OF NEWBOULDIA LAEVIS
Malaria is a parasitic protozoan disease caused by the protozoan parasites belonging to the genus Plasmodium. It is a major threat to health and constitutes medical and developmental challenge to individuals, communities...
FACTORS PREDICTING PNEUMONIA IN THE FIRST WEEK POST STROKE
Background: Post stroke infections (PSI) are a significant clinical problem with poor short and long term outcomes, The increased susceptibility to infections after stroke has been linked to a diverse set of factors that...
RELATIONSHIP BETWEEN BREASTFEEDING DURATION AND ACUTE RESPIRATORY INFECTIONS IN INFANTS: A CROSS SECTIONAL STUDY IN THE CHILD CENTRAL TEACHING HOSPITAL
Background: Human milk is the ideal and uniquely superior food for infants for the first year of life and as the sole source of nutrition for the first six months. Breast l'eeding is beneficial for both babies and mother...