Effect of Coronary Reperfusion Therapy on Inflammatory Markers, Adiponectin and Insulin Resistance in Ischemic Patients
Journal Title: International Journal of Medical and Health Sciences - Year 2018, Vol 7, Issue 2
Abstract
Background: Patients who underwent percutaneous coronary interventions (PCI) and surgical coronary artery bypass grafting (CABG) for coronary artery disease may have inflammatory response. Insulin resistance-associated dysfunction of lipid metabolism can promote both systemic and local inflammatory responses that participate in the development of coronary artery disease. Objective: The aim of our work is to determine the changes in serum adiponectin level, high sensitive C-reactive protein in patients who underwent PCI and surgical CABG for coronary artery disease and compare the effect of both revascularization procedures on these parameters in non-diabetic ischemic patients after one month. Also we investigated whether or not there was a relation between their levels and insulin resistance. Materials and Methods: 40 patients with ischemic heart disease who underwent the procedure of reperfusion therapy are reevaluated one month after intervention by either PCI or CABG. Serum adiponectin, insulin & high sensitive C-reactive protein were measured and insulin resistance was assessed using HOMA-IR index. Results: High sensitive C reactive protein, Insulin and adiponectin levels decreased significantly in patients after PCI with p-value <0.05.One month after revascularization, high sensitive C reactive protein and adiponectin levels were significantly higher in patients exposed to CABG in comparison to patients exposed to PCI. Insulin resistance as indicated by HOMA-IR was elevated in patients one month after CABG with p-value <0.05. Conclusion: PCI causes less reperfusion injury compared to CABG procedure depending on high sensitive C-reactive protein as predictor of reperfusion injury after revascularization by PCI in ischemic patients.
Authors and Affiliations
Hamed Mohamed Osman, Khaled Ahmad El Kashab, Amani M. El Amin Ali, Ahmed MagdyElebiary, Ahmed Desoky Badawy
Keywords
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