Effect of cycloporine A administration on aminothiols plasma concentration in children with idiopathic nephrotic syndrome
Journal Title: Medycyna Ogólna i Nauki o Zdrowiu - Year 2013, Vol 19, Issue 1
Abstract
Objective. Assessment of changes in plasma aminothiols metabolism in idiopathic nephrotic syndrome (INS) in children, with special consideration of the influence of cyclosporine A administration. Aminothiols are important elements of the red-ox balance in humans. The imbalance in red-ox status has been described in the nephrotic syndrome but may be a result of the disease itself or treatment (cyclosporine A).Materials and method. The study group covered 95 nephrotic children divided into 3 groups, i.e. in acute phase of the disease (30), during steroid-induced (37), and steroid-free remission (28). In each group, children treated with Cyclosporine A were selected for the study, and a control group of 32 healthy children. Aminothiols in plasma were assessed by high-performance liquid chromatography. Protein bound and free fractions of aminothiols were measured.results. Concentration of cysteine and homocysteine in nephrotic children were similar to controls. Only a few changes between stages of the disease were found. Free (toxic) homocysteine was elevated in early remission of INS. Glutathione concentration was not changed, whereas cysteinyloglycine concentration was decreased in first two stages of INS. Children treated with cyclosporine A showed significantly higher homocysteine and cysteine plasma concentrations in relapse and early remission of INS.Conclusion. Cyclosporine A may have a detrimental effect on the concentration of aminothiols promoting atherogenesis; however, the clinical importance of these observations requires further studies.Key words: nephrotic syndrome, atherosclerosis, red-ox balance, cyclosporine
Authors and Affiliations
Marcin Tkaczyk, Aneta Czupryniak, Grażyna Chwatko, Edward Bald, Wojciech Fendler
Keywords
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