Effect of Dialysis on Upper Gastrointestinal Symptoms and Endoscopic Findings Along with Biochemical Parameters in Patients of Chronic Renal Failure: A Cross-sectional Study in Tertiary Care Settings in North India
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 11
Abstract
Introduction: Chronic kidney disease (CKD) is defined as the presence of objective kidney damage or glomerular filtration rate (GFR) <60 ml/min/1.73 m2 or less for at least 3 months, irrespective of the underlying etiology of kidney damage. It affects almost every organ of body. GI manifestations of CKD present in as various symptoms and endoscopic findings are mostly inflammatory in nature. Materials and Methods: The present study Group 1 included 80 patients of chronic renal failure (28 patients of Stage 4 with estimated GFR [eGFR] of 15–29 ml/min/1.73m2) and 52 patients of Stage 5 with eGFR <15 ml/min/1.73 m2. Biochemical parameters and upper GI endoscopy were performed in all 80 patients, but 52 patients of Stage 5 were put on the active treatment of hemodialysis for 1–2 times/week for a period of varying from 1 month to as long as 1 year in the nephrology department. After dialysis, patients were subjected to endoscopic re-evaluation. Result: There were 80 patients Stages 4 and 5 of chronic renal disease. Mean age of patients was 56.73 ± 14.02 with a range of 18–80 years M: F = 1.42 (58.75%):1 (41.25%). There was a significant decrease in GI symptoms such as nausea and vomiting after dialysis (P < 0.05). Endoscopic findings when compared before and after dialysis, there was no significant change observed in abnormalities of esophagus, stomach, and duodenum on endoscope. However, biochemical analysis revealed that after dialysis, there was a significant improvement in the mean serum levels of urea, creatinine, potassium, calcium, phosphorus, and magnesium (P = 0.05). Conclusion: GI symptoms are common in CKD patients and constitute an important cause of morbidity and mortality. There was an improvement in few of upper GI symptoms/biochemical profile but no significant change in endoscopic findings following the hemodialysis therapy.
Authors and Affiliations
Swati Bhagat, Badrinath Bhougal, Vijant Singh Chandel, Rashmi Kumari, Shweta Bhagat, S K Bali
Keywords
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