EFFECT OF DIFFERENT FORMULATION VARIABLES ON RELEASE CHARACTERISTICS OF GASTRO-FLOATING MICROSPHERES OF ETHYL CELLULOSE/CARBOPOL 934P ENCAPSULATING SORAFENIB
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 10
Abstract
Objective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability. Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P were used as the encapsulating carriers. The effects of formulation parameters like, solvent volume ratio, and drug to polymer ratio (D: P ratio), encapsulation efficiency percentage EE%, floating percentage, and release of SFN after 12 h (Rel12) were investigated and analyzed using a (32) full factorial design. Results: The floating percentage of the microspheres was found to be 76.5%. The in vitro drug release from these hollow microspheres followed the Higuchi model equation. The in vivo results showed that approximately 1.96-fold improvement in the relative bioavailability of the microspheres compared with that of the commercial tablet. Conclusion: The results demonstrate that the hollow microspheres with good gastro-floating ability are a promising delivery system to enhance SFN bioavailability.
Authors and Affiliations
MAHMOUD M. AHMED
Keywords
Related Articles
- EP ID EP646244
- DOI 10.22159/ijpps.2019v11i10.34290
- Views 89
- Downloads 0
INCLUSION AND CHARACTERIZATION OF KETOPROFEN INTO DIFFERENT MESOPOROUS SILICA NANOPARTICLES USING THREE LOADING METHODS
Objective: The objective of the present study was to encapsulate ketoprofen into MCM-41, SBA-15 and uncalcined SBA-15 (unc SBA-15) using different loading methods. Investigate the effect of using different loading method...
EVALUATION OF CYTOTOXIC AND GENOTOXIC EFFECTS OF ZERUMBONE ON COLON ADENOCARCINOMA COLO205 CELLS AND HUMAN LYMPHOCYTES
Objective: The objective of the present study was to investigate the growth inhibitory effect, apoptosis initiation and genotoxic effect of zerumbone (ZER), a phytochemical and cisplatin, a chemotherapeutic drug on human...
APPLICATION OF STOOL ANTIGEN TEST FOR MONITORING HELICOBACTER PYLORI AMONG HUMAN IN ERBIL GOVERNORATE, KURDISTAN REGION/IRAQ
Objective: This work was connected to screen Helicobacter pylori among human in Erbil Governorate by using stool antigen test (SAT).Methods: In a clean and sterile container, three hundred stool samples were collected fr...
FORMULATION OF DICLOFENAC SODIUM SUSTAINED RELEASE TABLET USING COPROCESSED EXCIPIENTS OF CROSSLINKED AMYLOSE–XANTHAN GUM AS MATRIX
Objective: This present study was intended to design sustained release tablet containing diclofenac sodium using a matrix of excipient co-processed xanthan gum-crosslinked amylose.Methods: In the previous study, xanthan...
SCREENING OF ENDOPHYTIC BACTERIA PRODUCING ANTIFUNGAL ISOLATED FROM INDONESIA MEDICINAL PLANT, JAVA GINSENG (TALINUM TRIANGULARE) (JACQ.) WILLD
Objective: The objective of this research was to isolate and characterize endophytic bacteria from Talinum triangulare having antifungal activity.Methods: The endophytic bacteria were isolated from roots tissue of Talinu...