EFFECT OF ELECTROCONVULSIVE THERAPY ON SERUM SEROTONIN LEVEL IN PATIENTS WITH TREATMENT- RESISTANT MAJOR DEPRESSIVE DISORDER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 16
Abstract
BACKGROUND Previous studies have reported contrasting results about the effects of ECT on serotonin levels. We wanted to investigate the therapeutic effects of ECT on plasma serotonin levels in patients with major depressive disorder. METHODS In this cohort study, 36 patients with MDD were allocated to ECT group (n=21) and Non-ECT group (n=15). Plasma serotonin levels of the ECT group were measured before ECT, 15 minutes and 2-, 6-, and 24-hours, 16- and 30-days after treatment. In the Non-ECT group, measurement of serotonin was performed before drug therapy, 16 days and 30 days after drug therapy. Data was analysed with SPSS-16 using independent t-test, and repeated with ANOVA at a significance level of p ≤0.050. RESULTS The mean (±SD) age was 34.42 ± 13.77. In ECT group, the mean plasma serotonin levels before ECT, 15 minutes and 2-, 6-, and 24- hours, 16- and 30-days after treatment were 197.66 ± 81.24, 211.86 ± 79.30, 204.86 ± 62.14, 246.14 ± 98.60, 234.76 ± 101.42, 263.71 ± 100.14 and 263.81 ± 101.63 ng/ml respectively (p< 0.007). In the non- ECT group, the mean serotonin levels before drug therapy, 16 days and 30 days after drug therapy were 198.93 ± 84.38, 198.40 ± 84.98 and 195.93 ± 81.59 ng/ml respectively (p= 0.739). Mean plasma serotonin level 30 days after treatment in ECT group was higher than non-ECT group significantly (p= 0.040). CONCLUSIONS The results showed that plasma serotonin levels significantly increase following ECT in MDD patients. Perhaps, the faster effect of ECT than drug therapy is due to this issue. However, the rate of recovery in this study was not investigated.
Authors and Affiliations
Parvin Agha Mohammad Hasani, Fatemeh Mohseni Moghadam, Mohammadreza Mokhtaree, Mohammad Nazer
Keywords
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- EP ID EP564509
- DOI 10.14260/jemds/2019/286
- Views 66
- Downloads 0
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