EFFECT OF ERYTHROMYCINE IN ALTERED GASTRIC MOTILITY AND PH IN WISTAR RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
Drug absorption through the gastrointestinal tract plays a major role in determining the systemic exposure of the drugs when administered by oral route. The physicochemical properties of the drug like particle size, polymorphism, salt forms, lipophilicity and dosage form characteristics like disintegration time, dissolution time, manufacturing variables, pharmaceutical ingredients, nature and type of dosage form are known to impact drug absorption. Apart from physicochemical properties of drug various patient related factors like gastric emptying, gastric pH, intestinal transit, disease state and GI blood flow can affect the drug absorption to a huge extent. The change in the gastric emptying, intestinal transit and gastric pH in this study was accomplished by using Metoclopramide, Atropine, Neostigmine and Omeprazole. Metoclopramide also significantly increases the blood flow by about 67.3 and 29.7% at the duodenum and jejunum. In the present study, Patient related parameters were conducted for erythromycin in presence of metoclopromide, atropine, neostigmine and omeprazole in rats. Charcoal meal test were performed in rats to confirm the effect of above drugs on gastrointestinal motility.
Authors and Affiliations
Abhay Joshi , Prashant Tayade , Shrikant A Jagtap , Anasuya Patel , Yuvraj Girbane
Keywords
Related Articles
- EP ID EP129876
- DOI -
- Views 97
- Downloads 0
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CAPECITABINE IN BULK BY RP-HPLC METHOD
A simple, rapid and selective RP-HPLC method has been developed for quantification of Capecitabine from bulk drug using a mobile phase consisting mixture of methanol and buffer (70:30) (v/v) at the flow rate of 1.0 ml/mi...
SERUM VITAMIN LEVELS IN FEMALE WISTAR RATS ADMINISTERED WITH DIFFERENT DOSES OF PARACETAMOL AND PARACETAMOL/METHIONINE – AN ACUTE STUDY
Testosterone has been identified to play a role in the metabolism of paracetamol in the CD 1 mouse, resulting in differences in renal presentations of male and female mice. Moreover, alterations have been observed in the...
SCREENING AND MOLECULAR CHARACTERIZATION OF BACILLUS SP PR01 FOR THE PRODUCTION OF PROTEASE ENZYME
The current study was attempted to isolate and characterize the protease producing Bacillus sp. Among the 3 strains isolated from soil sample collected from kuppam region, Chennai, India. One strain (PR01) exhibited pote...
EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ALOCASIA MACRORRHIZOS ON MICE
The increased prevalence of depression at 12.3% rate and side effect profile of the existing antidepressants led to the present study which was designed to establish the role of natural herbal medicine Alocasia macrorrhi...