Effect Of Estradiol Progesterone Combination On Pregnancy In IVF-ICSI-ET Cycles
Journal Title: Acta Medica Ruha - Year 2023, Vol 1, Issue 3
Abstract
Objective:There are various treatment protocols in which different gonadotropins are used with orwithout pituitary down-regulation by using gonadotropin-releasing hormone (GnRH) agonists orantagonists. Since no single protocol suits every patient, the treatments should be individualized.Withinthe scope of this research, we aimed to elucidate the pregnancy rates achieved withprogesterone and progesterone estradiol (E2) combination for luteal phase (LP) support in ICSI –ET cycles with ovarian hyperstimulation using GnRH analog were compared.Method:This study evaluated 142 infertile couples aged between 20 and 40. Thepatients' admission histories and physical and pelvic examination findings were recorded. Basalserum FSH, LH, E2, prolactin, TSH, and free T3 –T4 levels were measured in each patient on thesecond or third day of the cycle. A long protocol with GnRH agonist was applied to all patients.Results:Of the 142 patients in the study, 71 were randomized (1:1) to receive vaginally gelprogesterone and transdermal estrogen for luteal phase support, and 71 to receive gel progesteronevaginally. When the cycles with and without pregnancy were evaluated independently of thegroups, a significant difference was found in terms of female age, male age, and mean gonadotropinamounts used (p<0.05). When the E2 measurements in the group with and without a pregnancywere examined, no significant difference was found in the basal E2 level, the E2 level on the hCGday, and the early luteal phase, that is, on the day of embryo transfer (p=0.788, p=0.735 andp=0.474, respectively). However, E2 levels were higher in pregnant women.Conclusion:In conclusion, data showing the superiority of one gonadotropin option over another inIVF/ICSI treatment cycles are insufficient. The choice of gonadotropin in controlled ovarianstimulation depends on the product’s availability and should be based on ease of use and cost.
Authors and Affiliations
Abdulgafur Alim Uçar
Keywords
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- EP ID EP722035
- DOI 10.5281/zenodo.8081453
- Views 22
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