EFFECT OF ETHANOLIC LEAF EXTRACTS OF CARICA PAPAYA AND NEWBOULDIA LAEVIS ON KIDNEY ENZYMES OF ALLOXAN-INDUCED DIABETIC WISTAR RATS.
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 5
Abstract
Objective: This study was carried out to investigate the effect of the ethanolic leaf extracts of C. papaya and N. laevis on kidney enzymes of alloxan-induced Wistar rats. Methodology: Forty male Wistar rats weighing between 160g – 200g were randomly assigned to eight Groups A - H of 5 rats each. Group A served as the control group and was not induced with diabetes, while Groups B – H were induced. Groups A and B received distilled water only, while Groups C - H received 200mg/kg of C. papaya, 400mg/kg of C. papaya, 200mg/kg of N. laevis, 400mg/kg of N. laevis, 200mg/kg of C. papaya + 200mg/kg of N. laevis and 400mg/kg of C. papaya + 400mg/kg of N. laevis respectively for 28 days. On day 29 of the experiment, the final weights of the animals were determined and they were sacrificed; blood samples were collected from each of the animals for serum analysis. Results: There were significant (P˂0.05) increase in serum levels of urea and creatinine of the animals in group B when compared with the control group. These effects were ameliorated in Groups C - H which received the variable doses of the ethanolic leaf extracts with more positive effects on the Groups that received the combined ethanolic leaf extracts. Conclusion: This study has revealed that ethanolic leaf extracts of C. papaya and N. laevis have ameliorative effects on the body weight and serum levels of urea and creatinine on alloxan-induced Wistar rats.
Authors and Affiliations
Mr. Ifegwu N. O.
Keywords
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