EVALUATION OF MICRORNA-93, MICRORNA-210 IN EGYPTIAN PATIENT WITH POST HCV HEPATOCELLULAR CARCINOMA
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 8
Abstract
Background: Hepatocellular carcinoma is one of the most highly malignant and lethal cancers of the world. The most urgent needs are to find sensitive markers for early diagnosis for HCC. MicroRNAs are conserved non-coding RNAs which regulate gene expression at the posttranscriptional level. They have been recently identified as important regulators that affect carcinogenesis. This study was conducted to detect the serum MiRNA 210 and MiRNA 93a to be applied as early detectors for HCC. Methods: A total of 60 serum samples (30 samples from HCC patients,15 samples from chronic Hepatitis c virus patients and 15 healthy control ) were collected. The levels of 2 mature miRNAs (miR-210 and miR-93 a) were detected by real time quantitative reverse-transcriptase PCR (RT-qPCR) in sera of the 60 subjects. Results: Results of the present study showed a higher mean baseline miR- 210 level in patients with HCC compared with cirrhotic and control subjects ( HCC, 4.25+ 6.18 ) VS (cirrhotic, 3.14+2.25) VS (control, 1.03+ 0.30),(P < 0.000). Conclusion: In conclusion, The expression of miRNA 210 and miRNA 93a was significantly upregulated in serum of patient with HCC, As a result miRNA 210 and miRNA 93a could be as potential circulating promising noninvasive early detectors for HCC and useful for screening in high risk vulnerable subjects.
Authors and Affiliations
Amal Tohamy Abdel Moez
Keywords
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