Effect of Glycyrrhiza uralensis Fisch polysaccharide on growth performance and immunologic function in mice in Ural City, Xinjiang
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2016, Vol 9, Issue 11
Abstract
Objective: To discuss the effect of Glycyrrhiza uralensis (G. uralensis) Fisch polysaccharide on growth performance and immunologic function in mice in Ural City, Xinjiang and to provide important data supporting the application of Glycyrrhiza polysaccharide. Methods: A total of 100 Kunming mice aged 3 weeks old were randomly divided into 5 groups with 20 mice in each group (10 were females and 10 were males). About 0.5 mL normal saline was given to the mice of control group every day and 0.5 mL G. uralensis Fisch polysaccharide was given to the mice of other groups at the concentration of 1, 20, 50 and 100 mg/mL, respectively. The growth performance (average body weight, average daily feed intake and feed efficiency), immune organ indexes (spleen index and thymus index) and immunologic function (serum IL-2, CD4+/CD8+ and the activity of NK cells) of mice in each group were detected continuously. Results: The average body weight, feed efficiency, serum IL-2, CD4+/CD8+ and the activity of NK cells of mice were increased with the increase of administrated time after administrating G. uralensis Fisch polysaccharide and were reached up the largest level on Day 28. At the same time, each index was proportional to the given dose and was significantly higher than those of control group and reached up the largest level at the administrated dose of 100 mg/mL. After administrating G. uralensis Fisch polysaccharide, the spleen index and thymus index of mice were increased with the increase of administrated dose and the spleen index and thymus index of mice administrated with the dose of 100 mg/mL were maximum which was more than 1.51 times and 1.43 times of that in control group, respectively and the comparative differences showed statistical significance (P < 0.05). The average daily feed intake of mice in each group was increased with the passage of time and at the same time, the comparison of average daily feed intake of mice in each group was not significantly different (P > 0.05). Conclusions: G. uralensis Fisch polysaccharide can significantly improve the growth performance and immunologic function of mice and laid a research basis for the clinical application of G. uralensis Fisch polysaccharide.
Authors and Affiliations
Jie Chen, Xin-Li Gu
Keywords
Related Articles
- EP ID EP281734
- DOI 10.1016/j.apjtm.2016.08.004
- Views 68
- Downloads 0
Healthcare workers' knowledge towards Zika virus infection in Indonesia: A survey in Aceh
Objective: To assess the knowledge on Zika virus infection among healthcare providers (doctors) in Aceh province, Indonesia. Methods: A self-administered internet based survey was conducted from 3 May to 3 June 2016 amon...
Identifications of drug resistance mutations among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia
Objective: To determine drug resistance mutations and the HIV-1 subtypes among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia. Methods: A total of 45 samples from four hospitals that provide HIV vir...
Wash resistance and bio-efficacy of Olyset® Plus, a long-lasting insecticide-treated mosquito net with synergist against malaria vector, Anopheles stephensi
Objective: To determine the wash resistance of Olyset® Plus using World Health Organization Pesticide Evaluation Scheme standard washing procedure and to assess the value of knock down and mortality rates of Anopheles st...
Solvent–solvent fractionations of Combretum erythrophyllum (Burch.) leave extract: Studies of their antibacterial, antifungal, antioxidant and cytotoxicity potentials
Objective: To evaluate the biological activities of Combretum erythrophyllum (C. erythrophyllum) leaf extracts against infectious diseases' pathogenesis and their cytotoxicity potentials. Methods: Powdered leaf material...
Evaluation of interleukin 8 +2767 A/T polymorphism in visceral leishmaniasis
Objective: To evaluated the relationship between the genetic variations at IL-8 +2767 position with VL pathogenesis among Iranian patients. Methods: Three groups including patients with VL clinical presentation and leish...