EFFECT OF HYDROGEN SULFIDE SYNTHESIS ENZYME INHIBITION BY ESTIMATION OF MUCIN IN PSYCHOLOGICAL STRESS-INDUCED ULCERS IN MICE
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract Objective: The present study was undertaken to evaluate the effect of Hydrogen Sulfide synthesis blocker induced enzyme inhibition by estimation of mucin in Psychological Stress-Induced Ulcers in Mice. Material and methods: Acute ulcers were induced in Swiss albino mice by using stress. The experimental groups consist of the following 2 groups: sender, responder groups. Sender animals received a foot shock of 10 sec duration at intervals of 50 sec for 3 hour. The electrical current for the shock 1.6 mA to 2.0 mA per hour for 3 day sender animals are changed daily. On day-3, after completing the foot-shock period, the responders were sacrificed, and their stomachs were removed. Drug (O- carboxy methyl hydroxylamine hemihydrochloride) was administered intraperitoneally with low (2mg/kg), medium (5 mg/kg), high (10 mg/kg) dose daily for 3 days respectively, 30 min before the shock period. Result: The proper development of ulcer with an average ulcer index of 5 mg/kg was found to be 33.42 which are significant with respect to control group. CBS at a dose of 5 mg/kg significantly increased the ulcer formation, which was corroborated by histopathology studies. Conclusion: The present study that observed inhibition of H2S synthesis blocker exacerbated the psychological stress induced ulcer implicacy an important role of H2S in regulator of stress.
Authors and Affiliations
Namrata Gupta1*, Dr. Pankaj V. Dixit2, Dr. Virendra Sharma1, Dr. Ashish Dixit1
Keywords
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