EFFECT OF HYDROTROPIC SOLUTE ON In-VitroCHARECTERIZATION OF VALSARTAN FAST DISINTEGRATING TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 4
Abstract
Valsartan is an angiotensin receptor antagonist, commonly called as “angiotensin receptor blocker", or angiotensin receptor blocker. Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. The poor solubility of drug substances in water and their low dissolution rate in aqueous gastro intestinal fluid often leads to insufficient bioavailability. Consequences of poor aqueous solubility would lead to failure in formulation of a dosage form. In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug valsartan by using hydrotropic solute, Sodium acetate. To increase the disintegration of the formulation some super disintegrants are used such as cross povidone, cross caremellose and sodium starch glycolate.This study revealed the influence of sodium acetate in the improvement of solubility of valsartan.
Authors and Affiliations
Madhu Sudhan Reddy A, Kishore Babu G, Srinivasa Babu P, Bhardwaj G
Keywords
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