RECENT TRENDS OF POLYMER USAGE IN THE FORMULATION OF ORODISPERSIBLE TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 2
Abstract
Disintegrants are an essential component to tablet formulations. While rapidly disintegrating tablets do not necessarily ensure fast bioavailability, slowly disintegrating tablets almost always assure slow bioavailability. The ability to interact strongly with water is essential to disintegrant function. Combinations of swelling and/or wicking and/or deformation are the mechanisms of disintegrant action. Super disintegrants offer significant improvements over starch. But hygroscopicity may be a problem in some formulations. Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegration remains a powerful influence and precursor for drug absorption. Disintegration of tablet or capsule is depending upon the type and quantity of disintegrants. The development of Orodispersible tablets provides an opportunity to take an account of tablet disintegrants. Therefore, there is a huge potential for the evaluation of new disintegrants or modification of an existing disintegrants into superdisintegrants, so as to formulate Orodispersible tablets. The present study comprises the various kinds of disintegrants and superdisintegrants, which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance.
Authors and Affiliations
J. Preethi, MD Farhana, B. Chelli Babu, MD. Faizulla, Debjit Bhowmik, S. Duraivel
Keywords
Related Articles
- EP ID EP33052
- DOI -
- Views 330
- Downloads 0
Thermogravimetric analysis of some samples of limestone available at Pidugurlla, Guntur district, Andhra Pradesh, India
TGA is one of the important techniques in thermal analysis. In Thermal analysis specific physical properties of materials are measured as a function of temperature production of new high technology materials and the re...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDIES ON LEAVES OF STEVIA REBAUDIANA LINN
Stevia rebaudiana (Bert) is a plant of compositae family and native to Paraguay, its sweetness and calorie free property increased its demand tremendously. It not only imparts the sweetness but also maintain the normal...
Design and development of buccoadhesive tablets of verapamil hydrochloride
Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Verapamil Hydrochloride is widely used in the management of Hypertension, Angi...
EVALUATION OF THE ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITY OF MADHUCA LONGIFOLIA (KOENIG) LEAVES
The study was designed to evaluate the antioxidant and hepatoprotective activity of 70% ethanolic extract of Madhuca longilolia (Koenig) in experimental liver injury produced by carbon tetrachloride. The effects observ...
Development and validation of new RP-HPLC method for simultaneous estimation of drug Thiocolchicoside and Etodolac in tablet dosage form
A simple, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Thiocolchicoside and Etodolac was developed and validated according to ICH guidelines. The quantifica...