Evaluation of hypoglycemic activity of aqueous extract of bark of Ficus bengalensis linn. in alloxan induced diabetic rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
Objective: Evaluation of Hypoglycemic activity of Extract of bark of Ficus bengalensis Linn. In alloxan induced diabetic albino rats and comparison with standard drug Glibenclamide. Methods: Aqueous extract of bark of Ficus bengalensis was evaluated for hypoglycemic activity. Albino rats were divided into five groups of six-animals each. Diabetes was induced by using Alloxan monohydrate (180mg/kg.b.w:i.p).control group was treated with normal saline 0.5; second group was treated with Glibenclamide 5mg/kg as a standard drug. Remaining 2 groups were treated with different doses (150 & 300mg/kg.b.w) of bark of F.bengalensis for a period of 28 days. Fasting glucose level estimated by using Glucometer on days 3, 7, 14, 21 and 28. Results: An Aqueous Extract of F.benglensis Linn. produced significant regulation of fasting blood glucose in diabetic rats. At the dose of 300mg/kg showed significant fall in blood glucose level as compared to 150mg/kg.b.w. Post-prandial reduction of blood glucose levels on day 3 after 3hrs of drug administration was significant (p value< 0.07) with bark 300mg as compared to other doses. This is however, highly significant (p value<0.0001) when compared with standard drug Glibenclamide Conclusions: Further study can be evaluated for its potential antidiabetic activity.
Authors and Affiliations
Arati Chikaraddy, Yasmeen A Maniyar
Keywords
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