OPTIMIZATION OF THIOCOLCHICOSIDE TABLET WITH PERMEATION ENHANCERS USING 32 FACTORIAL DESIGN
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 4
Abstract
Thiocolchicoside has a selective affinity for g-amino-butyric acid (GABA) receptors and acts on the muscular contracture by activating the GABA-nergic inhibitory pathways thereby acting as a potent muscle relaxant Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It is used for the treatment of orthopedic, traumatic and rheumatologic disorders. It is currently administered by the oral, injective and topical routes. The physico-chemical properties of Thiocolchicoside are not favorable for its permeation across the skin. Thiocolchicoside has a relatively high molecular weight (563), relatively high water solubility (16.1mg/ml) and low octanol/water partition coefficient (logP=-0.34). The various Permeation enhancers were used in different ratio and its permeation enhancement is done by using Franz diffusion cell. The Data Expert software is applied for the 32 factorial design and the ANOVA study of the linear regression model, response surface plot as well as contour plot confirms the predicted batch with the desirability of 0.982. Result of R2 and T-test confirmed that predicted and observed responses showed no significant difference. The optimized batch was found to be B2 showing disintegrating agent 40 mg and binder 2.5 mg quantity with the best response.
Authors and Affiliations
Devendra Singh, Pankaj Kumar Sharma, Udai Vir Singh Sara
Keywords
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