FORMULATION, CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF DICLOFENAC SODIUM TABLETS THROUGH SOLID DISPERSION USING POLY ETHYLENE GLYCOL
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
In the present study the formulation of Diclofenac sodium tablet from poly ethylene glycol solid dispersion has been carried to enhance the bioavailability and solubility of the drug, Diclofenac. The post compression studies were carried out for the prepared solid dispersion and the compressed tablets and, it was found that all the parameters were in the limits. All the formulations showed rapid release when compared to Diclofenac sodium immediate release marketed tablets. The drug release after 90 minutes of dissolution was 28.35% for marketed tablet and for tablets formulated with solid dispersion was 95.62% with Diclofenac sodium: PEG-6000 combination.
Authors and Affiliations
Harish Gopinath, Haritha M, Duraivel S, Debjit Bhowmik, Sangeetha S
Keywords
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