HPTLC: A versatile method for rapid analysis of pharmaceutical formulations and comparison with other chromatographic techniques and its applications
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
Analysis of pharmaceutical and natural compounds and newer drugs is commonly used in all the stages of drug discovery and development process. HPTLC is an advanced type of planar chromatography used extensively in the recent years for fingerprinting of medicinal plants, products and for screening lichen substances. Major advantages include precise sample application, wide choice of stationary phases, simultaneous processing of standards, simultaneous scanning in different light sources and excellent documentation facility. It is more sensitive and possible to run more samples in a short period of time, by using small amount of solvent. It is one of the sophisticated instrumental techniques based on the full capabilities of thin layer chromatography. In the present review brief discussion is presented with regard to type of instrument used in HPTLC, its entire methodology and how this technique is better than TLC. This concise information consists of salient points showing immense use in the practical analysis of HPTLC. This article consists of compilation of 63 formulations in total, out of which 38 containing one active substances and 25 containing dual active substances are shown in separate Tables (Table 1 and 2). The names of products, solvent system, details of plates to be used and details of quantitation showing densitometric evaluation are shown against each formulation.
Authors and Affiliations
P. Ravisankar, Ch. Lokapavani, Ch. Devadasu, G. Devala Rao
Keywords
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