Formulation and evaluation of vildagliptin sustained release tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
The main aim of proposed work was to develop Vildagliptin matrix tablets, sustained release dosage form, for the treatment anti-diabetic drug. Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by contineously releasing medication over an extended period of time after administration of single dose. The sustained release tablets were prepared by direct compression method using Hydroxylpropylmethyl cellulose (K15M), Dicalcium phosphate, Metalose (60SH-50) and Karayagum, Guar gum,carbopol 971P in varying ratios. Tablets blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability, and drug content. Formulation F1 to F24 direct compression method, sustain release and among all the formulation, F14 formulation was compared with the marketed product for drug release pattern.
Authors and Affiliations
Shaik. Allabaksh, Debjit Bhowmik, Nanda Kishore Agarwal, K. P. Sampath Kumar, Praveen Khirwadkar
Keywords
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