FORMULATION DEVELOPMENT AND EVALUATION OF LOPERAMIDE HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
There is an increasing demand for more patient compliant dosage form and a novel method is the development of orally disintegrating tablets which dissolve or disintegrates instantly on the patient tongue or buccal mucosa. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. Loperamide hydrochloride is a drug of choice for diarrhoea. Loperamide hydrochloride has systemic bioavailability too low due to extensive hepatic first pass metabolism. Hence the main objective of the study was to formulate orally disintegrating tablets of Loperamide hydrochloride to achieve a better dissolution rate and further improving the bioavailability of the drug and to get relief from diarrhoea very quickly. Orally disintegrating tablets prepared by direct compression and using super disintegrant crosspovidone were prepared and evaluated for the pre- compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability,drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among the 6 groups (f1, f2, f3, f4, f5, f6),formulation f4 emerged as the best formulation and showed rapid dissolution rate i.e. it releases 95% drug in 5 min.
Authors and Affiliations
A Bharathi, K Mohan Guptha, Y Uma Jagannadha Rao
Keywords
Related Articles
- EP ID EP33013
- DOI -
- Views 482
- Downloads 0
Evaluation of in-vitro anthelminthic activity of leaf and bark aqueous extracts of Santalum album linn
Santalum album Linn is the most significant genus in the family Santalaceae, which is commonly known as Sri gandham in India. This study evaluates anthelmintic activity of Aqueous leaf and bark extracts of Santalum alb...
Effect of ethanol/water extract of Crinum jagus on glycemia, lipids parameters and body weight gain on high-sugar diet fed rats
Crinum jagus is used in Cameroon western region folk medicine in the management of diabetes and obesity. The effects of ethanol/water extract of C. jagus were evaluated on two month old Wistar rats submitted to a high...
Formulation and evaluation of osmotic controlled release verapamil tablets
Controlled release tablets of verapamil based on osmotic technology was developed and evaluated. Verapamil half life2.8-7.4 Hrs, it is short acting drug, developed formulation provide the prolong controlled release for...
Studies of relative and specific viscosities of Aceclofenacin 70% Dioxane water mixture at different temperature
Acelofenac drug plays their own identity in the drug, pharmaceutical and medicinal sciences in last decades. Hence, the viscometric study were carried out at 70% various percentage of solvent. The result obtained durin...
Formulation and evaluation of diclofenac sodium S.R. tablets using Linum usitatissimum seed mucilage Matrixing
The main accusative of the present work was to develop sustained release matrix tablets of Diclofenac sodium for maintaining therapeutic blood or tissue levels of the drug for extended period of time with minimized loc...