Phytochemical and anti diarrhoeal activity of Hippocratea africana roots
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
Diarrhoea is a condition that involves frequent passing of loose or watery stools. According to the Who, approximately 3.5million deaths each year are attributable to diarrhoea. Medicinal plants have been used as traditional remedy for diarrhoea for years long and there is renewed interest from the discovery of novel compounds from plants to flight against diarrhoea. WHO also encourages studies on diarrhoea which include research on traditional herbs. The present study was designed to investigate antidiarrhoeal potential of 70% hydro ethanolic extract of Hippocratea africana extract. Castor oil introduced diarrhoea in Wister rats. Phyto-chemical screening of the plant extract for their active constituents was also carried out using standard procedures. Oral administration of hydro ethanolic extract of Hippocratea africana extract significantly, and dose dependently delayed the onset of diarrhoea induced by castor oil and also significantly reduced the number of diarrhoeal episodes and number of animals exhibiting diarrhoea. The results were comparable with standard synrhetic antidiarrhoeal drug, lopeeramide. Phytochemical screening also revealed the presence of alkaloids, tannins, flavonoids; carbohydrates as the major constituents. The results point out the presence of active principles in hippocratea africanaextract possessing a promising antidiarrhoeal effect substantiate the useof herb non specific treatment of diarrhoea in folk medicine.
Authors and Affiliations
K. Rajeswari, A Ravi Kumar, K M Subbu Rathinam
Keywords
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