Phytochemical and anti diarrhoeal activity of Hippocratea africana roots
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
Diarrhoea is a condition that involves frequent passing of loose or watery stools. According to the Who, approximately 3.5million deaths each year are attributable to diarrhoea. Medicinal plants have been used as traditional remedy for diarrhoea for years long and there is renewed interest from the discovery of novel compounds from plants to flight against diarrhoea. WHO also encourages studies on diarrhoea which include research on traditional herbs. The present study was designed to investigate antidiarrhoeal potential of 70% hydro ethanolic extract of Hippocratea africana extract. Castor oil introduced diarrhoea in Wister rats. Phyto-chemical screening of the plant extract for their active constituents was also carried out using standard procedures. Oral administration of hydro ethanolic extract of Hippocratea africana extract significantly, and dose dependently delayed the onset of diarrhoea induced by castor oil and also significantly reduced the number of diarrhoeal episodes and number of animals exhibiting diarrhoea. The results were comparable with standard synrhetic antidiarrhoeal drug, lopeeramide. Phytochemical screening also revealed the presence of alkaloids, tannins, flavonoids; carbohydrates as the major constituents. The results point out the presence of active principles in hippocratea africanaextract possessing a promising antidiarrhoeal effect substantiate the useof herb non specific treatment of diarrhoea in folk medicine.
Authors and Affiliations
K. Rajeswari, A Ravi Kumar, K M Subbu Rathinam
Keywords
Related Articles
- EP ID EP33221
- DOI -
- Views 264
- Downloads 0
Assessment of Hepatoprotective Potential of Solanum xanthocarpum (whole plant) Linn. Against Isoniazid & Rifampicin Induced Hepatic Toxicity in Wistar rats
Introduction and objective: The scientific assessment of medicinal plants used in the preparation of folk remedies has contributed modern medicine with effective pharmaceuticals for the treatment of diseases. Objective...
The curious case of prion proteins:Are they a friend or foe? A review & perspective
Transmissible spongiform encephalopathies (TSE) in humans were known to be caused by prion proteins (PrPC). Recent research has although revealed that prions are an enigmatic protein & their identity holds much more th...
A review on biotransformation
Biotransformation means chemical alteration of chemicals such as nutrients, amino acids, toxins, and drugs in the body. It is also needed to render nonpolar compounds polar so that they are not reabsorbed in renal tubu...
A NOVEL RP- HPLC METHOD DEVELOPMENT AND VALIDATION OF ATORVASTATIN AND FENOFIBRATE IN BULK AND PHARMACEUTICAL DOSAGE FORMS
A fast, robust and accurate RP-HPLC method was developed and validated for simultaneous determination of Losartan potassium and Amlodipine in tablets. The mobile phase was mixture of aqueous Tri ethyl amine with pH 2.0...
NEUROPHARMACOLOGICAL SCREENING OF ETHANOLIC EXTRACT OF NELUMBO NUCIFERA GAERTNER SEEDS
The neuropharmacological activities of the ethanolic extract of Nelumbo nucifera Gaertneer seeds were screened in mice and rats. The extracts effect on phenobarbitone sodium induced sleep latency and sleeping time,moto...