NEUROPHARMACOLOGICAL SCREENING OF ETHANOLIC EXTRACT OF NELUMBO NUCIFERA GAERTNER SEEDS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The neuropharmacological activities of the ethanolic extract of Nelumbo nucifera Gaertneer seeds were screened in mice and rats. The extracts effect on phenobarbitone sodium induced sleep latency and sleeping time,motor coordination activity,locomotor activity,anxiolytic activity(light-dark model transition in mice,elevated zero maze),cerebral activator activity(nootropic) were evaluated. The ethanolic extract of Nelumbo nucifera (50,100 and 200 mg/kg p.o) possess a significant (p<0.05) depression in general behavioral tests, and potentiation of phenobarbitone induced sleeping time, and also shows anxiolytic action, in dose dependent manner.The ethanolic extract of Nelumbo nucifera gaertnershows nootropic activity on Conditional avoidance response, Morri’s water maze for spatial learning, but it weakly acts on acetylcholineesterase enzyme inhibitory activity.Earlier studies conducted by various workers have revealed that several medicinal plants possess nootropic activity, but only a few plants like W.somnifera possess both antistress as well as nootropic activity. Similarly, our studies demonstrate that the plant nelumbo nucifera possesses a combination of activities. As discussed earlier, these properties are complementary to each other and hence the plant could be a valuable contribution to the existing armamentarium of nootropic agent having antistress activity.
Authors and Affiliations
Sirisha Chowdary G
Keywords
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