Phytochemical studies and anti-ulcer activity of Limonia acidissima linn. leaf in treating ethanol induced ulcer Albino rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 3
Abstract
The preliminary phytochemical analysis of Limonia acidissima plant leaf, showed the presence of alkaloids, flavonoids, steroids, saponins, glycosides, phenols, gum and mucilage, fixed oils and fats, resins and tannins. The objective of the present investigation is to elucidate the anti-ulcer activity of ethanolic leaf extract of Limonia acidissima in ethanol induced GIT damage in albino rats. The lyophilized extract was given by oral gavages (200mg/kg and 400mg/kg) before administering ethanol at 1ml/kg. Pre-treatment with extract significantly decreased the ulcerated area. The volume and acidity of the gastric juice decreased in the pre-treated rats. In conclusion, L. acidissima was able to decrease the acidity and increase the mucosal defense in the gastric areas, there by justifying its use as an anti-ulcerogenic agent.
Authors and Affiliations
A. Aneesha, N. Rama Rao, N. Siva Naga Tejaswini, A. Lakshmi Sai Durga, Sk. Haseena, B. Maneesha
Keywords
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