Design and evaluation of fast dissolving tablet of Mefenamic acid by direct compression technique
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
The demand for fast disintegrating tablets has been growing during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. Mefenamic acid is mainly indicated for to overcome the inflammation, however, it is also prescribed for the prophylaxis of premenstrual migraine headache. Hence, in the present work an attempt has been made to formulate fast dissolving tablets of Mefenamic acid by direct compression technique using various concentrations of super disintegrants like cross carmellose sodium (Ac-Di-Sol), Trigonella Foenum-graceum and Plantago ovata. The formulated tablets were evaluated for crushing strength, friability, thickness, diameter, weight variation, wetting time, water absorption ratio, disintegration time, and percentage of drug release. All formulations showed satisfactory result. Among them formulation F5 containing 2% of Trigonella Foenum-graceum exhibited complete disintegration time was within 10 seconds. Dissolution data was exhibited an acceptable value >50. All parameters were within the limit of acceptance.
Authors and Affiliations
M. Sumathi, B. Senthilkumar, S. Rithika, G. Tamilselvan, Muhammed Sadique K P and Lingesh V
Keywords
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