A comprehensive review on superdisintegrants used in orodispersible tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
Orodispersible Tablets disintegrate and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fastdissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. When put on tongue, this tablet disintegrates instantaneously, releasing the drug, which dissolves or disperses in the saliva. Some drugs are absorbed from the mouth, pharynx and oesophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form. Their growing importance was underlined recently when European Pharmacopoeia adopted the term “Orodispersible Tablet” as a tablet that to be placed in oral cavity where it disperses rapidly before swallowing.
Authors and Affiliations
Digpati Roy, Debjit Bhowmik, K. P. Sampath Kumar
Keywords
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