Formulation and evaluation of immediate release Carvedilol tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 6
Abstract
The present study aims at developing a carvedilol immediate release tablet formulation for the effective treatment of congestive heart failure (CHF), as an adjunct to conventional treatments (ACE inhibitors and diuretics). The use of carvedilol has been shown to provideadditional morbidity and mortality benefits in severe CHF. To provide the patient with the most convenient mode of administration, there was need to develop immediate release dosage form, particularly one that disintegrates rapidly and disperse and help in enhancing the bioavailability of the drug. The absolute bioavailability of carvedilol is approximately 25%. Plasma levels peak approximately one hour after an oral dose.Carvedilol undergoes stereoselective first-pass metabolism. Carvedilol immediate release tablets were formulated by using direct compression method and crocarmellose sodium, sodium starch glycolate, crospovidone disintegrants, magnesium stearatate as lubricant.the tablet were evaluated for pre compression and post compression parameters after conducting pre-formulation studies. All the parameters were within the pharmacopoeial limits and drug disintegration time was less and the invitro dissolution Studies showed that the drug release was fast in Formulation (F6) containing croscaramellose sodium as super disintegrant.
Authors and Affiliations
Shafi Shaik, B. Pragathi Kumar, Harish. G
Keywords
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