EFFECT OF KONDAGOGU ON THE RELEASE BEHAVIOUR OF AMBROXOL HYDROCHLORIDE MATRIX TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 11
Abstract
The aim of present research work was to study the effect of kondagogu on the release behavior of ambroxol hydrochloride sustained delivery dosage forms. Oral dosage forms containing 75mg Ambroxol hydrochloride in matrix tablets were formulated by wet granulation technique. The tablets were subjected to physical parameters like thickness, weight variation, friability and drug content etc. In vitro drug release studies of these formulations were studied at pH 1.2 buffer for the first 2hrs and in pH 6.8 phosphate buffer for the next 10hrs using the USP dissolution apparatus with the paddle assemble. Results shows that kondagogu alone not protect the drug up to 12 hrs. Polymers of (kondagogu and guargum) blend protects the drug and extends the release rate till 12 hrs. The kinetics of the dissolution process was studied by analyzing the dissolution data using Higuchi and Korsemeyer kinetics. Optimzed formulation was followed higuchi release profile that is diffusion mediated.
Authors and Affiliations
Indira Muzib, Sree. Padma
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