Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyper responsiveness and clinical asthma in nonsteroiddependent asthma in children

Journal Title: Medpulse International Journal of Pediatrics - Year 2018, Vol 7, Issue 2

Abstract

Several short-term studies have shown that inhaled steroids can reduce airway hyper responsive in asthma. To evaluate whether prolonged treatment can bring about full recovery, this double blind, randomized, control trial by systematically examined the effect of budesonide, 400 μg daily for 1 yr. on the airway hyper responsiveness over a period of 6 yrs. The time course and characteristics of improvements and associated changes in clinical asthma severity were also paralelly evaluated. Sixty two stable asthmatics, requiring bronchodilators alone, were selected for study. Monthly study of airway-responsiveness severity of clinical asthma was assessed by questionnaire by daily bronchodilator use, and by number of asthmatic exacerbations. Patients receiving budesonide showed a fourfold mean improvement in airway responsiveness compared with those receiving placebo (p < 0.005), whose responsiveness remained very stable. Sixty of the budesonide subjects improved and returned to the normal. Largest improvements occurred during the first 4 months but, in some progress was continued for one year. Impovements in responsiveness were accompanied by significant improvements in asthma symptoms, bronchodilator use, and number of asthma-exacerbations. The results show that regular, prolonged use of inhaled steroid can produce remarkable improvements in airway hyperresponsiveness, sometimes with a full remission. These improvement are accompanied by clinically significant improvements in clinical childhood asthma.

Authors and Affiliations

Akhilesh Bisaria, R E Bhingare, N Pipliwal

Keywords

Related Articles

Quality of life among school going children with asthma

Asthma is a major cause of chronic respiratory problem in childhood. It is one of the most frequent admitting diagnosis in children’s hospitals and is an important cause for school days lost. Asthma prevalence seems to b...

Incidence and distribution of congenital malformations in newborns at a tertiary teaching hospital in Kolhapur Maharashtra

Background: According to the World Health Organization (WHO) document of 1972, the term congenital malformations should be confined to structural defects at birth. Aims and Objectives: To study Incidence and Distribution...

Study of hematological and coagulation profile of term neonates born to mothers with PIH as compared to term neonates born to normotensive mothers

Objectives: To study the changes in Hematological and Coagulation profile of newborns born to mothers with hypertensive disorders of pregnancy and in neonates born to normotensive mothers. Methods: A prospective study to...

Significance of lactate and its clearance within 6 hours of admission in children with sepsis and septic shock admitted to PICU

Aims and Objective: To measure the serum lactate levels in patient with sepsis and septic shock. To determine and correlate lactate clearance within 6 hours of admission with sepsis and septic shock, with PICU mortality....

Urodynamic study in enuretic children

Background: Nocturnal enuresis is probably the most common developmental disorder affecting 15-20% of children of 5 years age. Urodynamic study (UDS) today is a compilation of the results obtained by cystometry, uroflowm...

Download PDF file
  • EP ID EP414052
  • DOI -
  • Views 93
  • Downloads 0

How To Cite

Akhilesh Bisaria, R E Bhingare, N Pipliwal (2018). Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyper responsiveness and clinical asthma in nonsteroiddependent asthma in children. Medpulse International Journal of Pediatrics, 7(2), 27-29. https://europub.co.uk/articles/-A-414052