Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyper responsiveness and clinical asthma in nonsteroiddependent asthma in children
Journal Title: Medpulse International Journal of Pediatrics - Year 2018, Vol 7, Issue 2
Abstract
Several short-term studies have shown that inhaled steroids can reduce airway hyper responsive in asthma. To evaluate whether prolonged treatment can bring about full recovery, this double blind, randomized, control trial by systematically examined the effect of budesonide, 400 μg daily for 1 yr. on the airway hyper responsiveness over a period of 6 yrs. The time course and characteristics of improvements and associated changes in clinical asthma severity were also paralelly evaluated. Sixty two stable asthmatics, requiring bronchodilators alone, were selected for study. Monthly study of airway-responsiveness severity of clinical asthma was assessed by questionnaire by daily bronchodilator use, and by number of asthmatic exacerbations. Patients receiving budesonide showed a fourfold mean improvement in airway responsiveness compared with those receiving placebo (p < 0.005), whose responsiveness remained very stable. Sixty of the budesonide subjects improved and returned to the normal. Largest improvements occurred during the first 4 months but, in some progress was continued for one year. Impovements in responsiveness were accompanied by significant improvements in asthma symptoms, bronchodilator use, and number of asthma-exacerbations. The results show that regular, prolonged use of inhaled steroid can produce remarkable improvements in airway hyperresponsiveness, sometimes with a full remission. These improvement are accompanied by clinically significant improvements in clinical childhood asthma.
Authors and Affiliations
Akhilesh Bisaria, R E Bhingare, N Pipliwal
Keywords
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