Effect of mechanical force on hypertrophic scar and research progress of TGFβ1 / Smad pathway in its mechanism
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 5
Abstract
Hypertrophic scars (HPs), which often occur after abnormal wound healing, are pathological scars caused by excessive collagen synthesis and abnormal hyperplasia after skin tissue damage. It is a kind of skin fibroproliferative disease. At present, the treatment methods of HPs mainly include injection therapy, drug therapy, laser therapy, radiotherapy, cryotherapy, pressure therapy, mechanical tension reduction and surgery. However, before surgical treatment, people often prefer non-surgical treatments to inhibit and reduce scar formation. In addition, for patients with large-area burns or trauma, surgical treatment often has many limitations. Therefore, non-surgical treatments and prevention of scar formation are the focus of current research. According to a large number of literature reports, continuous mechanical tension can induce the formation of HPs and mechanical pressure is currently one of the most effective methods for the treatment of HPs. TGFβ1 / Smad signaling pathway plays an important role in regulating collagen synthesis and scar formation. Many studies have also shown that regulating the TGFβ1 / Smad signaling pathway also plays a crucial role in the treatment and prevention of pathological scar formation. The treatment and prevention of HPs is one of the worldwide problems faced by clinicians. Although a large number of scholars have conducted many studies on the treatment and prevention of HPs, the exact and effective treatment and prevention methods for this clinical problem have not been fully elucidated. Therefore, it is very necessary to review and analyze the effect of mechanical force on HPs and the research progress of TGFβ1 / Smad pathway in its mechanism.
Authors and Affiliations
CAO Peng, WANG Yunwei, YAO Ming, LI Shaohui, CHEN Yang, ZHANG Hao, GUAN Hao
Keywords
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