Research progress in the antihypertensive effect of targeted inhibition of hepatogenic AGT
Journal Title: Journal of Air Force Medical University - Year 2023, Vol 44, Issue 8
Abstract
Renin-angiotensin system ( RAS) plays an important role in the development of hypertension, and angiotensinogen ( AGT) is the sole substrate of this system. With the advance of RNA interference and gene editing technology, the inhibition of hepatogenic AGT has shown a good clinical prospect, which can reduce blood pressure continuously and steadily and improve the structure and function of target organs in hypertension. Based on the latest studies, this paper describes the structure and role of AGT gene, the classification of methods for inhibiting hepatogenic AGT, and the effects of inhibiting hepatogenic AGT on RAS molecules, hypertension and target organs, so as to provide a reference for antihypertensive treatment of inhibiting hepatogenic AGT.
Authors and Affiliations
YU Shuiqing, YANG Xiuhong, SHI Guohui
Keywords
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