Effect of methanolic extract of Alchornea cordifolia leaves on the sexual behavior of senescent and sexually inexperienced rats
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 6
Abstract
Alchornea cordifolia, a shrub found in tropical Africa, is used to treat several physiological disorders, including male infertility and impotency. The main objective of this study was to determine the effect of the methanolic extract of Alchornea cordifolia leaves on the sexual behavior of senescent and sexually inexperienced rats. In order to evaluate aphrodisiac properties and reproductive performance, rats were divided into groups: group I receiving distilled water, group II receiving testosterone, group III receiving sildenafil citrate, group IV and V receiving the methanolic extract of Alchornea cordifolia leaves at 200 mg / kg and 400 mg / kg, respectively. The treatment was done by gavage for groups I, III, IV and V and subcutaneous injection of testosterone every three days for group II for 14 days. On days 1, 7 and 14, the rats were mated to the receptive females. At the end of this last treatment, the rats were mated with gonad-intact females. 14 days after of treatment, the extract leads to an increase in libido and sexual performance parameters (mounts, intromissions and ejaculations frequency) and an increase in sexual desire (decrease of mount and intromission latency). The extract also prolonged the duration of coitus by increasing the ejaculation latency and the average interval of copulation. An increase in the percentage of female’s rats impregnated as well as the numbers of implantations were recorded in females’ rats mated with the males treated with our extract. These results reveal the potential of the methanolic extract of Alchornea cordifolia leaves to improve male reproductive performance justifying its use in traditional medicine.
Authors and Affiliations
Marie Ide Ngaha Njila, Goh Yong Meng, Mahdi Ebrahimi, Elmutaz Atta Awad, Falah Hasan Baiee, Hubert Kenmogne, Brice Landry Koloko, Magloire Hambe, Samuel Honoré Mandenguè, Dieudonné Massoma Lembè
Keywords
Related Articles
- EP ID EP589848
- DOI -
- Views 109
- Downloads 0
Role of phytotherapy in diabetic neuropathy and neurodegeneration: from pathogenesis to treatment
Diabetes mellitus is a metabolic disorder associated with structural and functional alterations of various organ systems. Tissue injury is attributed primarily to chronic hyperglycemia. Diabetic complications are associa...
Medicinal plants used by tribal and rural community of Sata Pokhran area of tehsil Pampore of district Pulwama, Jammu and Kashmir-India
Man has used plants since time immemorial to alleviate sufferings and ailments. The present study attempts to explore and document the medicinal plants used against several diseases by the tribal and rural community of S...
Pharmacological activity of Fumaria indica - A review
Fumaria indica (Hausskn.) Pugsley (Fumariaceae), known as “Fumitory”, is an annual herb found as a common weed all over the plains of India and Pakistan. Plant is used widely used in Unani and Ayurvedic system of medicin...
Adding value to wild Himalayan fig (Ficus palmata): Composition, functional and sensory characteristics of jam
Wild Himalayan fig is an underutilized wild fruit with various nutritional components. The fruit was evaluated for different parameters like crude fibre value (18.90 - 16.38 %), total phenols (72.6 – 65.4 mg/100g) and th...
Allablanckia floribunda hypotensive activity on ethanol induced hypertension in rats
Background: Chronic alcohol intake is related to hypertension. In the present work, we investigated the effect of Allablanckia floribunda Oliver (Clusiaceae) aqueous extract in alcohol-induced hypertensive rats and on re...